公开(公告)号：EP1309569A2

公开(公告)日：2003-05-14

申请号：EP01973654.5

申请日：2001-08-17

申请人： Millennium Pharmaceuticals, Inc. ,  KYOWA HAKKO KOGYO CO., LTD. ,  Pandey, Anjali ,  Scarborough, Robert M. ,  Matsuno, Kenji ,  Ichimura, Michio ,  Nomoto, Yugi ,  Fujiwara, Shigeki ,  Ide, Shinichi ,  Tsukuda, Eiji ,  Irie, Junko ,  Oda, Shoji

发明人： PANDEY, Anjali ,  SCARBOROUGH, Robert, M. ,  MATSUNO, Kenji ,  ICHIMURA, Michio ,  NOMOTO, Yuji ,  FUJIWARA, Shigeki ,  IDE, Shinichi ,  TSUKUDA, Eiji ,  IRIE, Junko ,  ODA, Shoji

IPC分类号： C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12

摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

公开(公告)号：EP1315715A1

公开(公告)日：2003-06-04

申请号：EP01964612.4

申请日：2001-08-17

申请人： Millennium Pharmaceuticals, Inc. ,  Kyowa Hakko Kogyo Co., Ltd ,  Pandey, Anjali ,  Scarborough, Robert M. ,  Matsuno, Kenji ,  Ichimura, Michio ,  Nomoto, Yugi ,  Ide, Shinichi ,  Tsukuda, Eiji ,  Irie, Junko ,  Oda, Shoji

发明人： PANDEY, Anjali ,  SCARBOROUGH, Robert, M. ,  MATSUNO, Kenji ,  ICHIMURA, Michio ,  NOMOTO, Yuji ,  IDE, Shinichi ,  TSUKUDA, Eiji ,  IRIE, Junko ,  ODA, Shoji

IPC分类号： C07D403/12 ,  C07D239/94 ,  C07D401/12

CPC分类号： C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D403/12

摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.