公开(公告)号：EP2791337A1

公开(公告)日：2014-10-22

申请号：EP12818596.4

申请日：2012-12-11

申请人： Oncostamen S.r.l.

发明人： DE MARIA MARCHIANO, Ruggero ,  COPPOLA, Valeria ,  TODARO, Matilde ,  FIORI, Micol Eleonora ,  GARACI, Enrico

IPC分类号： C12N15/113 ,  A61P35/00 ,  A61K31/712

CPC分类号： C12N15/1135 ,  A61K31/337 ,  A61K31/7105 ,  A61K31/712 ,  A61K33/24 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/3231

摘要： The invention relates to molecular targets and their use to counteract tumors. Naturally occurring microRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri- miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The here claimed approach is efficacious also on Cancer Stem Cells.

公开(公告)号：EP2816114A3

公开(公告)日：2015-02-25

申请号：EP14184761.6

申请日：2012-12-11

申请人： Oncostamen S.r.l.

发明人： De Maria Marchiano, Ruggero ,  Coppola, Valeria ,  Todaro, Matilde ,  Fiori, Micol Eleonora ,  Garaci, Enrico

IPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/712 ,  A61P35/00

CPC分类号： C12N15/1135 ,  A61K31/337 ,  A61K31/7105 ,  A61K31/712 ,  A61K33/24 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/3231

摘要： The invention relates to pharmaceutical compositions comprising an antagonist of hsa-miR-361-3p or hsa-miR-1285 and their use to counteract tumors, in particular of the breast or lung. Said compositions may further contain a chemotherapeutic drug.

公开(公告)号：EP2816114A2

公开(公告)日：2014-12-24

申请号：EP14184761.6

申请日：2012-12-11

申请人： Oncostamen S.r.l.

发明人： De Maria Marchiano, Ruggero ,  Coppola, Valeria ,  Todaro, Matilde ,  Fiori, Micol Eleonora ,  Garaci, Enrico

IPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/712 ,  A61P35/00

CPC分类号： C12N15/1135 ,  A61K31/337 ,  A61K31/7105 ,  A61K31/712 ,  A61K33/24 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/3231

摘要： The invention relates to pharmaceutical compositions comprising an antagonist of hsa-miR-361-3p or hsa-miR-1285 and their use to counteract tumors, in particular of the breast or lung. Said compositions may further contain a chemotherapeutic drug.

摘要翻译： 本发明涉及包含hsa-miR-361-3p或hsa-miR-1285的拮抗剂的药物组合物及其用于抵抗特别是乳腺或肺的肿瘤的用途。 所述组合物还可以含有化学治疗药物。

公开(公告)号：EP2604690A1

公开(公告)日：2013-06-19

申请号：EP11193873.4

申请日：2011-12-15

申请人： Oncostamen S.r.l.

发明人： Coppola, Valeria ,  De Maria Marchiano, Ruggero ,  Fiori, Micol Eleonora ,  Garaci, Enrico ,  Todaro, Matilde

IPC分类号： C12N15/113

CPC分类号： C12N15/111 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/3231 ,  C12N2320/12

摘要： The invention relates to molecular targets and their use to counteract tumors. Naturally occurring microRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The here claimed approach is efficacious also on Cancer Stem Cells.

摘要翻译： 本发明涉及分子靶标及其用于抵抗肿瘤的用途。 描述了调节人癌基因的天然存在的微小RNA及其使用方法。 用于本文描述的方法和组合物的合适的核酸包括但不限于保留成熟miRNA的生物活性的pri-miRNA，前miRNA，成熟miRNA或其变体的片段，编码pri- miRNA，前miRNA，成熟miRNA，其片段或变体，或miRNA的调节元件。 这里声称的方法也对癌细胞有效。