公开(公告)号：EP2959000B1

公开(公告)日：2018-08-15

申请号：EP14708460.2

申请日：2014-02-24

申请人： Integrated DNA Technologies Inc. ,  Behlke, Mark Aaron ,  Lennox, Kimberly Ann ,  Jacobi, Ashley Mae ,  Owczarzy, Richard ,  Walder, Joseph Alan

发明人： BEHLKE, Mark, Aaron ,  LENNOX, Kimberly, Ann ,  JACOBI, Ashley, Mae ,  OWCZARZY, Richard ,  WALDER, Joseph, Alan

IPC分类号： C12N15/113 ,  A61K31/00

CPC分类号： C12N15/111 ,  A61K31/7125 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/352 ,  C12N2320/51 ,  C12N2310/3521

摘要： The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic siRNAs and miRNAs.

公开(公告)号：EP2959000A1

公开(公告)日：2015-12-30

申请号：EP14708460.2

申请日：2014-02-24

申请人： Integrated DNA Technologies Inc. ,  Behlke, Mark Aaron ,  Lennox, Kimberly Ann ,  Jacobi, Ashley Mae ,  Owczarzy, Richard ,  Walder, Joseph Alan

发明人： BEHLKE, Mark, Aaron ,  LENNOX, Kimberly, Ann ,  JACOBI, Ashley, Mae ,  OWCZARZY, Richard ,  WALDER, Joseph, Alan

IPC分类号： C12N15/113 ,  C12N15/11 ,  A61K31/00

CPC分类号： C12N15/111 ,  A61K31/7125 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/352 ,  C12N2320/51 ,  C12N2310/3521

摘要： The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic siRNAs and miRNAs.

摘要翻译： 本发明涉及反义寡核苷酸的修饰，其中所述修饰用于改善稳定性并提供对核酸酶降解的保护。 这些修饰也可以并入双链核酸，如合成siRNA和miRNA。