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1.发明授权
公开(公告)号：EP1464646B1
公开(公告)日：2009-09-30
申请号：EP04076527.3
申请日：2001-10-30
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00 , A61P9/10 , A61P25/28 , A61P29/00
CPC分类号： C07D495/04
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2.发明授权
公开(公告)号：EP2313418B1
公开(公告)日：2016-03-30
申请号：EP09767722.3
申请日：2009-06-18
发明人： PELLICCIARI, Roberto , MORONI, Flavio , HANSEN, Eric, Christian , GILBERT, Adam, Matthew , LARKIN, Peter, John
IPC分类号： C07D493/04 , C07D495/04 , A61K31/4741 , A61K31/4743 , A61K31/5377
CPC分类号： C07D495/04 , C07D491/048
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3.发明授权THIAZOLYL- AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM 有权噻唑基和OXAZOLYLISOCHINOLINONE和申请流程。
公开(公告)号：EP2303895B1
公开(公告)日：2014-09-24
申请号：EP09767711.6
申请日：2009-06-18
IPC分类号： C07D513/04 , A61K31/4745 , A61K31/5377 , A61P25/00 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/437 , A61K31/4745 , C07D513/04
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4.发明公开Thiazolyl- and oxazolyl-isoquinolinones and methods for using them 审中-公开维多利亚ZU DEREN ANWENDUNG的THIAZOLYL- UND OXAZOLYLISOCHINOLINONE
公开(公告)号：EP2896626A1
公开(公告)日：2015-07-22
申请号：EP14185672.4
申请日：2009-06-18
IPC分类号： C07D513/04 , A61K31/4745 , A61K31/5377 , A61P9/10
CPC分类号： A61K31/5377 , A61K31/437 , A61K31/4745 , C07D513/04
摘要： The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl- isoquinolinones and to their use in treating various diseases and disorders.
摘要翻译： 本发明涉及作为例如聚（ADP-核糖）聚合酶（PARP）的调节剂的取代的噻唑基 - 和恶唑基 - 异喹啉酮。 本发明还涉及制备取代的噻唑基 - 和恶唑基 - 异喹啉酮的方法及其在治疗各种疾病和病症中的用途。
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5.发明公开4-SULFONYL-SUBSTITUTED BENZOYLALANINE DERIVATIVES USEFUL AS KYNURENINE-AMINOTRANSFERASE INHIBITORS 审中-公开-4-磺酰BENZOYLALANINDERIVATE所产生作为适合KYNURENINAMINOTRANSFERASE抑制剂的
公开(公告)号：EP1781602A1
公开(公告)日：2007-05-09
申请号：EP05775813.8
申请日：2005-08-02
IPC分类号： C07C317/48 , A61K31/198 , A61P25/00
CPC分类号： C07C317/48
摘要： The invention relates to compounds of formula (I), in which R, R' and R' are as defined in the disclosure and the pharmaceutically acceptable esters thereof. The compounds of the invention reduce the synthesis of kynurenic acid thus inhibiting the enzyme kynurenine aminotransferase and can be used for the preparation of medicaments for the treatment of those psychiatric and neurological diseases which benefit from an increase in glutamatergic and/or cholinergic neurotransmission, such as depression, bipolar illness, anxiety, Alzheimer's disease. Furthemore, the compounds of the invention are useful for stimulating attention, memory and other cognitive processes in normal individuals of any age, including children, adolescents and the elderly.
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公开(公告)号：EP1392714A1
公开(公告)日：2004-03-03
申请号：EP02750526.2
申请日：2002-02-21
申请人： PELLICCIARI, Roberto
发明人： PELLICCIARI, Roberto
IPC分类号： C07J9/00 , A61K31/575 , A61P9/10
CPC分类号： C07J9/005 , C07C215/08 , C07C215/10 , C07C215/12 , C07J9/00 , C07J41/0055 , C07J43/00 , Y10S514/893
摘要： The invention relates to compounds of formula (I): wherein R is ethyl and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
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