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公开(公告)号：EP0416722B1
公开(公告)日：1994-09-28
申请号：EP90307385.6
申请日：1990-07-06
申请人： PITMAN-MOORE LIMITED
发明人： Baker, Rodney Cyril
CPC分类号： A61K9/0068
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公开(公告)号：EP0416722A3
公开(公告)日：1992-09-09
申请号：EP90307385.6
申请日：1990-07-06
申请人： PITMAN-MOORE LIMITED
发明人： Baker, Rodney Cyril
CPC分类号： A61K9/0068
摘要： A solid pharmaceutical composition for release of a biologically active substance into a desired aqueous environment, containing a core and an outer layer, said core comprising between 17 and 93% by weight of the biologically active substance, between 0.01 and 7% by weight of a water swellable polymer material and between 0 and 83% of one or more accessory ingredients, relative to the total weight of the core; and the outer layer comprising between 25 and 75% by weight of the biologically active substance, between 25 and 75% by weight of a material for enabling rapid dispersion of the outer layer into the aqueous environment and 0 to 50% by weight of one or more accessory ingredients, relative to the total weight of the outer layer. The composition is preferably formulated as a bolus for veterinary use.
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公开(公告)号：EP0441475A3
公开(公告)日：1992-03-11
申请号：EP91300061.8
申请日：1991-01-04
申请人： PITMAN-MOORE LIMITED
发明人： McHardy, Nicholas
IPC分类号： A61K31/505 , A61K31/635
CPC分类号： A61K31/63 , A61K31/505 , A61K31/635 , A61K2300/00
摘要： The antibacterial substance baquiloprim (2,4-diamino-5-[8-dimethylamino-7-methyl-5-quinolylmethyl] pyrimidine) is shown to be active against protozoal infections, e.g. toxoplasmosis. Preferably the baquiloprim is administered together with a sulphonamide.
摘要翻译： 抗菌物质baquiloprim（2,4-二氨基-5- [8-二甲基氨基-7-甲基-5-喹啉基甲基]嘧啶）显示出对抗原虫感染的活性。 弓形虫病。 优选地，将巴曲酮与磺酰胺一起施用。
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公开(公告)号：EP0384722A1
公开(公告)日：1990-08-29
申请号：EP90301842.2
申请日：1990-02-21
申请人： PITMAN-MOORE LIMITED
IPC分类号： A61K31/635
CPC分类号： A61K31/635 , A61K31/505 , A61K2300/00
摘要： A composition comprising the compounds 2,4-diamino-5-(8-dimethylamino-7-methyl-5-quinolylmethyl)pyrimidine and sulphadimethoxine or salts- thereof useful for treating bacterial infections in small domestic animals.
摘要翻译： 一种组合物，其包含2,4-二氨基-5-（8-二甲基氨基-7-甲基-5-喹啉基甲基）嘧啶化合物和磺胺二甲氧基或其盐，其可用于治疗小型家畜中的细菌感染。
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公开(公告)号：EP0316163A3
公开(公告)日：1990-06-27
申请号：EP88310571.0
申请日：1988-11-10
申请人： PITMAN-MOORE LIMITED
发明人： Dassanayake, Lincoln
IPC分类号： A61K31/365 , A61K31/71
CPC分类号： A61K31/70 , A61K31/365
摘要： The antibiotic compound M139603 (tetronasin), disclosed in GB-A-2027013 as a growth-promotant in farm animals with activity against Gram-positive bacteria, has now been found to prevent and treat Treponem a hyodysenteriae infections in pigs (swine dysentery). Analogues of M139603 have the same action. The compound is administered in the pig's food or water supply.
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6.发明公开Baquiloprim for treating protozoal infections 失效Baquiloprim zur Behandlung von Infektionen mit Protozoen。
公开(公告)号：EP0441475A2
公开(公告)日：1991-08-14
申请号：EP91300061.8
申请日：1991-01-04
申请人： PITMAN-MOORE LIMITED
发明人： McHardy, Nicholas
IPC分类号： A61K31/505 , A61K31/635
CPC分类号： A61K31/63 , A61K31/505 , A61K31/635 , A61K2300/00
摘要： The antibacterial substance baquiloprim (2,4-diamino-5-[8-dimethylamino-7-methyl-5-quinolylmethyl] pyrimidine) is shown to be active against protozoal infections, e.g. toxoplasmosis. Preferably the baquiloprim is administered together with a sulphonamide.
摘要翻译： 抗菌物质baquiloprim（2,4-二氨基-5- [8-二甲基氨基-7-甲基-5-喹啉基甲基]嘧啶）显示出对抗原虫感染的活性。 弓形虫病。 优选地，将巴曲酮与磺酰胺一起施用。
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7.发明公开Tetronasin or derivatives thereof for veterinary treatment 失效Tetronasin und Derivate zurveterinärenBehandlung。
公开(公告)号：EP0316163A2
公开(公告)日：1989-05-17
申请号：EP88310571.0
申请日：1988-11-10
申请人： PITMAN-MOORE LIMITED
发明人： Dassanayake, Lincoln
IPC分类号： A61K31/365 , A61K31/71
CPC分类号： A61K31/70 , A61K31/365
摘要： The antibiotic compound M139603 (tetronasin), disclosed in GB-A-2027013 as a growth-promotant in farm animals with activity against Gram-positive bacteria, has now been found to prevent and treat Treponem a hyodysenteriae infections in pigs (swine dysentery).
Analogues of M139603 have the same action.
The compound is administered in the pig's food or water supply.摘要翻译： 现已发现在GB-A-2027013中公开的作为抗革兰氏阳性细菌活性的农场动物中的生长促进剂的抗生素化合物M139603（tetronasin），以预防和治疗Treponem猪（猪痢疾）中的猪痢疾螺旋体感染。 M139603的类似物具有相同的作用。 该化合物在猪的食物或水源中施用。
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公开(公告)号：EP0284406A1
公开(公告)日：1988-09-28
申请号：EP88302656.9
申请日：1988-03-25
申请人： PITMAN-MOORE LIMITED
发明人： James, Stephen , Aston, Roger , Bomford, Robert
摘要： A peptide having primary structural homology to a continuous sequence of amino acid residues of growth hormone in the region spanning positions 35 to 53 or antigenically equivalent peptides thereto or salts thereof, may be used in an antigenic formulation to potentate the effects of growth hormone in a vertebrate.
摘要翻译： 在跨越位置35至53的区域或与其抗原等同的肽或其盐的生长激素的氨基酸残基的连续序列具有初级结构同源性的肽可用于抗原制剂中以增强生长激素在 脊椎动物。
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公开(公告)号：EP0205342B1
公开(公告)日：1991-11-27
申请号：EP86304445.9
申请日：1986-06-10
申请人： PITMAN-MOORE LIMITED
CPC分类号： A61K9/0068 , A61M31/002
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公开(公告)号：EP0205342A2
公开(公告)日：1986-12-17
申请号：EP86304445.9
申请日：1986-06-10
申请人： PITMAN-MOORE LIMITED
CPC分类号： A61K9/0068 , A61M31/002
摘要： The invention relates to improvements in boluses for releasing a biologically active substance into a liquid environment. These boluses comprise a generally elongate core (25) surrounded by a liquid impermeable casing (11), (13), (15). In use, the casing has an opening at one (27) or both ends of the core and is progressively shed as the core retreats, to release the active substance at a rate which varies over at least one time period. The main improvement resides in that the bolus casing is (or at least some of its components are) sufficiently strong to retain integrity without disintegrating in the absence of any support provided by the core.
摘要翻译： 本发明涉及用于将生物活性物质释放到液体环境中的丸剂的改进。 这些推注包括由液体不可渗透的外壳（11），（13），（15）包围的大致细长的芯部（25）。 在使用中，壳体在芯的一个（27）或两端具有开口，并且随着芯部后退而逐渐脱落，以至少在一个时间段内变化的速率释放活性物质。 主要的改进在于，弹丸套管（或其至少一些部件）足够坚固以保持完整性而不会在没有由芯提供的任何支撑的情况下分解。
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