公开(公告)号：EP3126836A4

公开(公告)日：2017-11-08

申请号：EP15772587

申请日：2015-04-01

申请人： PRINCE HENRY'S INSITUTE OF MEDICAL RES TRADING AS THE HUDSON INST OF MEDICAL RES

发明人： SALAMONSEN LOIS ,  EDGELL TRACEY ,  HANNAN NATALIE ,  ROMBAUTS LUK

IPC分类号： G01N33/53 ,  A61K35/54 ,  C12Q1/68

CPC分类号： G01N33/689 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/49 ,  G01N2333/52 ,  G01N2333/535 ,  G01N2333/5421 ,  G01N2800/368

摘要： The present disclosure teaches an assay to determine the likelihood of a successful implantation of an embryo into a female subject leading to a pregnancy. Enabled herein is an improved assisted reproduction technology protocol based on a prognostic evaluation of pregnancy outcomes. Taught herein is a composition comprising reagents required for the prognostic evaluation. Taught herein are assays comprising determination of levels of the biomarkers IL-8, G-CSF and/or VEGFA in a biological fluid sample taken before embryo implantation.