公开(公告)号：EP2387564A1

公开(公告)日：2011-11-23

申请号：EP10700793.2

申请日：2010-01-15

申请人： Rutgers, The State University of New Jersey ,  University Of Medicine And Dentistry Of New Jersey ,  Kaul, Malvika ,  Parhi, Ajit

发明人： KAUL, Malvika ,  PARHI, Ajit ,  PILCH, Daniel S. ,  LAVOIE, Edmond J.

IPC分类号： C07D221/12 ,  A61K31/473 ,  A61P31/04

CPC分类号： C07D221/12

摘要： The present invention provides compounds of formula I: formula (I) wherein X
1 - X
4 and R
1 -R
12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections.