-
1.发明授权IMPROVED COMPOSITIONS AND METHODS FOR CHEMODENERVATION USING NEUROTOXINS 失效FOR化学去神经改良的组合物和方法与NEURO毒素
公开(公告)号：EP0773788B1
公开(公告)日：2003-05-07
申请号：EP96917968.8
申请日：1996-06-04
申请人： Pearce, L. Bruce
发明人： Pearce, L. Bruce , First, Eric R.
CPC分类号： A61K38/4886 , A61K38/4893 , Y02A50/469
摘要： The compositions and methods disclosed herein utilize admixtures of neurotoxins to cause denervation which is unexpectedly more localized and of longer duration than otherwise occurs with single neurotoxins. The compositions and methods of the invention utilize neurotoxin admixtures calibrated in median paralysis units rather than LD50s. Admixtures of neurotoxins include, but are not limited to, the botulinum serotypes A-G and tetanus toxin. The clinical benefits of the disclosed invention include: lengthening intervals between neurotoxin treatments; reducing adverse immunogenic responses to neurotoxins; and, reducing adverse diffusion-dependent side-effects of neurotoxin treatments.
-
2.发明公开IMPROVED COMPOSITIONS AND METHODS FOR CHEMODENERVATION USING NEUROTOXINS 失效FOR CHEMODENERVIERUNG改进的组合物和方法与NEURO毒素
公开(公告)号：EP0773788A1
公开(公告)日：1997-05-21
申请号：EP96917968.0
申请日：1996-06-04
申请人： Pearce, L. Bruce
发明人： Pearce, L. Bruce
IPC分类号： A61K38
CPC分类号： A61K38/4886 , A61K38/4893 , Y02A50/469
摘要： The compositions and methods disclosed herein utilize admixtures of neurotoxins to cause denervation which is unexpectedly more localized and of longer duration than otherwise occurs with single neurotoxins. The compositions and methods of the invention utilize neurotoxin admixtures calibrated in median paralysis units rather than LD50s. Admixtures of neurotoxins include, but are not limited to, the botulinum serotypes A-G and tetanus toxin. The clinical benefits of the disclosed invention include: lengthening intervals between neurotoxin treatments; reducing adverse immunogenic responses to neurotoxins; and, reducing adverse diffusion-dependent side-effects of neurotoxin treatments.
-
搜索结果
2 条记录 (耗时 0.009 秒)
