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公开(公告)号：EP3763292A1
公开(公告)日：2021-01-13
申请号：EP20170530.8
申请日：2014-03-06
申请人： Profusa, Inc.
IPC分类号： A61B5/1455
摘要： An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.
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公开(公告)号：EP3313288A1
公开(公告)日：2018-05-02
申请号：EP16815486.2
申请日：2016-06-27
申请人： Profusa, Inc.
IPC分类号： A61B5/1459 , G01N21/00
CPC分类号： A61B5/14542 , A61B5/0059 , A61B5/01 , A61B5/14503 , A61B5/686 , A61B5/7203 , A61B2562/166
摘要： Some embodiments described herein relate to a reader having a distributed source of radiation and a photodetector. The photodetector can be operable to sense radiation (e.g., light) emitted by an implanted sensor. The distributed source of radiation can at least partially surrounds the photodetector. The distributed source of radiation generates a photon cloud of excitation radiation within the skin, which can substantially envelopes a sensor that is implanted within the skin at a depth that is on the order of a centimeter or less.
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公开(公告)号：EP2967454A1
公开(公告)日：2016-01-20
申请号：EP14775668.8
申请日：2014-03-06
申请人： Profusa, Inc.
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/7203
摘要： An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.
摘要翻译： 使用光学装置来监测嵌入哺乳动物组织（例如皮下）的植入物。 植入物接收来自光学装置的激发光并发射由光学装置检测到的包括分析物依赖性光学信号的光。 由于水合作用，血液灌注和氧合作用的变化，组织的散射和吸收特性随时间变化。 光学装置具有光源，滤波器和检测器的布置，以传输激发波长范围内的激发光并测量检测波长内的发射光。 监测组织中光散射和吸收的变化，例如漫反射。 光源，滤光片和检测器也可用于监测组织中的自发荧光以纠正自发荧光背景。
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公开(公告)号：EP4449978A2
公开(公告)日：2024-10-23
申请号：EP24158962.1
申请日：2011-10-06
申请人： Profusa, Inc.
IPC分类号： A61B5/00
摘要： Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.
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公开(公告)号：EP3777656A1
公开(公告)日：2021-02-17
申请号：EP20176588.0
申请日：2014-06-06
申请人： Profusa, Inc.
IPC分类号： A61B5/00
摘要： Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.
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公开(公告)号：EP3488871B1
公开(公告)日：2020-09-02
申请号：EP18200504.1
申请日：2014-03-13
申请人： Profusa, Inc.
IPC分类号： A61K49/00 , C07D487/22 , G01N21/64 , C09K11/06 , G01N33/497
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公开(公告)号：EP2967454A4
公开(公告)日：2016-11-16
申请号：EP14775668
申请日：2014-03-06
申请人： PROFUSA INC
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/7203
摘要： An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.
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公开(公告)号：EP3003131B1
公开(公告)日：2020-05-27
申请号：EP14807637.5
申请日：2014-06-06
申请人： Profusa, Inc.
IPC分类号： A61B5/00
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公开(公告)号：EP3488871A1
公开(公告)日：2019-05-29
申请号：EP18200504.1
申请日：2014-03-13
申请人： Profusa, Inc.
IPC分类号： A61K49/00 , C07D487/22 , G01N21/64 , C09K11/06
摘要： Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
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公开(公告)号：EP2970318A1
公开(公告)日：2016-01-20
申请号：EP14775010.3
申请日：2014-03-13
申请人： Profusa, Inc.
IPC分类号： C07D487/22 , G01N21/64
CPC分类号： A61B5/14552 , A61B5/0059 , A61B5/14532 , A61B2503/40 , A61K49/0036 , A61K49/0054 , A61K49/0073 , C07F15/0066 , C09K11/06 , C09K2211/185 , C12Q1/54 , G01N33/497 , G01N2333/904
摘要： Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
摘要翻译： 提供氧感测发光染料，包含这些传感器的聚合物和传感器以及使用这些传感器和系统的方法。
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