公开(公告)号：EP1611174A1

公开(公告)日：2006-01-04

申请号：EP04726071.6

申请日：2004-04-07

申请人： Rimon Therapeutics Ltd.

发明人： MAY, Michael, H. ,  SKARJA, Gary

IPC分类号： C08F220/34 ,  C08F220/60

CPC分类号： C08F246/00 ,  A01N37/44

摘要： The invention relates to an ancient defense polymer having biological activity. The polymer comprises both discrete hydrophilic blocks containing cationic charge(s) and discrete hydrophobic blocks, making it amphipathic and antimicrobial in a manner analogous to natural antimicrobial peptides that form an ancient defense mechanism employed by many organisms. Such a polymer may be formed into devices designed to resist infection or bound to the surface of an apparatus to lend the biological activity to the surface of the apparatus.

公开(公告)号：EP1890740A4

公开(公告)日：2013-01-09

申请号：EP06761062

申请日：2006-06-19

申请人： RIMON THERAPEUTICS LTD

发明人： SKARJA GARY A ,  HO REBECCA K ,  MAY MICHAEL H

IPC分类号： A61L15/24 ,  A61K9/00 ,  A61L15/44 ,  A61L15/46 ,  A61L27/16 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61L27/54 ,  A61K9/0024 ,  A61K9/009 ,  A61L27/16 ,  A61L27/56 ,  A61L2300/00 ,  C08L33/12

公开(公告)号：EP1890740A1

公开(公告)日：2008-02-27

申请号：EP06761062.6

申请日：2006-06-19

申请人： Rimon Therapeutics Ltd.

发明人： SKARJA, Gary A. ,  HO, Rebecca K. ,  MAY, Michael H.

IPC分类号： A61M1/00 ,  A61J1/00 ,  A61F2/00

CPC分类号： A61L27/54 ,  A61K9/0024 ,  A61K9/009 ,  A61L27/16 ,  A61L27/56 ,  A61L2300/00 ,  C08L33/12

摘要： An implantable or surface-applied device comprising a porous polymeric pouch containing a therapeutic polymer sealed in the pouch, to provide a localized therapeutic effect at the site of the application. The pores in the polymeric pouch being smaller than the therapeutic polymer, allowing body fluid to enter and exit the pouch and interact with the therapeutic polymer in the pouch in use, but not permitting the therapeutic polymer to leave the pouch.

公开(公告)号：EP1877111A1

公开(公告)日：2008-01-16

申请号：EP06721786.9

申请日：2006-04-07

申请人： Rimon Therapeutics Ltd.

发明人： BUTLER, Mark J. ,  SEFTON, Michael Vivian ,  SKARJA, Gary Alan

IPC分类号： A61L27/56 ,  A61L27/14 ,  A61K35/12 ,  A61L27/58 ,  A61L27/60 ,  C08J5/00

CPC分类号： A61L27/16 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2300/10 ,  C08J2333/02 ,  C08L33/08

摘要： A pro-angiogenic porous polymer scaffold is disclosed. The polymer has at least 20 mol-% monomeric subunits containing acidic functional groups, and has a porosity of at least 40%. The pores in the scaffold are interconnected. A method of making such a scaffold using a novel adaptation to the traditional solvent casting/particulate leaching technique technique is also disclosed. The scaffold may be used for tissue regeneration.

公开(公告)号：EP1781714A1

公开(公告)日：2007-05-09

申请号：EP04737914.4

申请日：2004-07-02

申请人： Rimon Therapeutics Ltd.

发明人： SEFTON, Michael, V. ,  MAY, Michael, H. ,  SKARJA, Gary, A.

IPC分类号： C08F8/32 ,  C07C259/06 ,  C08F20/58 ,  A61K31/785 ,  A61L15/00

CPC分类号： A61L27/16 ,  A61L24/06 ,  A61L26/0014 ,  C08F8/32 ,  C08L33/12 ,  C08F220/00 ,  C08F120/14

摘要： Therapeutic polymers containing hydroxamate group that binds and thus inhibits zinc containing enzymes such as matrix metalloproteinases. The implantation fo such material inhibits remodeling in its vicinity.