公开(公告)号：EP3368689A2

公开(公告)日：2018-09-05

申请号：EP16795490.8

申请日：2016-10-28

申请人： The Broad Institute Inc. ,  Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Regev, Aviv ,  Anderson, Ana C. ,  Cong, Le ,  Kuchroo, Vijay K. ,  Singer, Meromit ,  Wang, Chao

发明人： REGEV, Aviv ,  ANDERSON, Ana, Carrizosa ,  CONG, Le ,  KUCHROO, Vijay, K. ,  SINGER, Meromit ,  WANG, Chao

IPC分类号： C12Q1/68 ,  C12N5/0783

CPC分类号： C12Q1/6886 ,  C12N5/0636 ,  C12N2510/00 ,  C12Q1/6881 ,  C12Q2600/158

摘要： The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.

公开(公告)号：EP3314020A1

公开(公告)日：2018-05-02

申请号：EP16741186.7

申请日：2016-06-29

申请人： The Broad Institute Inc. ,  Massachusetts Institute of Technology ,  Dana-Farber Cancer Institute, Inc. ,  The General Hospital Corporation ,  Garraway, Levi A. ,  Izar, Benjamin ,  Prakadan, Sanjay ,  Regev, Aviv ,  Rozenblatt-Rosen, Orit ,  Shalek, Alexander K. ,  Suva, Mario ,  Tirosh, Itay ,  Venteicher, Andrew ,  Wadsworth, Marc II ,  Bernstein, Bradley ,  Parikh, Anuraag ,  Puram, Sidharth

发明人： GARRAWAY, Levi, A. ,  IZAR, Benjamin ,  PRAKADAN, Sanjay ,  REGEV, Aviv ,  ROZENBLATT-ROSEN, Orit ,  SHALEK, Alexander, K. ,  SUVA, Mario ,  TIROSH, Itay ,  VENTEICHER, Andrew ,  WADSWORTH, Marc, II ,  BERNSTEIN, Bradley ,  PARIKH, Anuraag ,  PURAM, Sidharth

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158

摘要： This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells, and provides compositions and methods of modulating expression of genes and gene networks of tumors, tissues and cells, as well as methods of identifying, designing and selecting appropriate treatment regimens. The invention also relates to the modulation of complement activity to shift cellular immunity and obtain an effective therapeutic response.