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1.发明公开6-ARYL PYRAZOLO 3,4-d]PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF 失效6 - 芳基 - 吡唑并（3,4-D）嘧啶-4- ONE，组合物和使用过程中FOR THEIR
公开(公告)号：EP0813534A4
公开(公告)日：1998-06-10
申请号：EP96907191
申请日：1996-03-05
申请人： SANOFI WINTHROP INC
发明人： BACON EDWARD R , SINGH BALDEV
IPC分类号： A61K31/505 , A61P9/00 , A61P9/12 , C07D487/04 , A61K31/535 , A61K31/54 , A61K31/55
CPC分类号： C07D487/04
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2.发明公开SUBSTITUTED 2-(PHOSPHINYLOXYMETHYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF 失效取代的2-（PHOSPHINYLOXYMETHYL）-1,2,5-噻二唑烷-3- ON-1,1-二氧化物和组成以及方法的使用
公开(公告)号：EP0794956A4
公开(公告)日：1998-02-11
申请号：EP95940884
申请日：1995-11-30
申请人： SANOFI WINTHROP INC
发明人： COURT JOHN J , DESAI RANJIT C
IPC分类号： A61K31/675 , A61K31/683 , A61P1/00 , A61P11/00 , A61P29/00 , A61P43/00 , C07F9/6539 , C07F9/6561 , C07F9/09
CPC分类号： C07F9/6561 , C07F9/65397
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3.发明公开SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO 3,4-b QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF 失效取代的N-芳基甲基和杂环基-1H-吡唑并3,4-B喹啉-4-胺，及其组合物和FOR USE方法
公开(公告)号：EP0813410A1
公开(公告)日：1997-12-29
申请号：EP96908695
申请日：1996-03-05
申请人： SANOFI WINTHROP INC
发明人： KUMAR VIRENDRA , DORITY JOHN A JR
IPC分类号： A61K31/435 , A61K31/4745 , A61P9/00 , A61P9/12 , C07D471/04 , A61K31/47 , A61K31/50 , A61K31/505 , A61K31/535 , C07D241/20 , C07D401/14 , C07D413/12
CPC分类号： C07D471/04 , A61K31/4745
摘要： Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.
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4.发明公开
公开(公告)号：EP0764167A4
公开(公告)日：1997-09-17
申请号：EP95923013
申请日：1995-06-08
申请人： SANOFI WINTHROP INC
IPC分类号： C07D487/04 , A61K31/535 , A61K31/55 , A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D471/04 , C07D513/04 , C07K5/02 , C07K5/06 , C07K5/078 , A61K31/435 , A61K31/495 , A61K31/675 , C07D417/04 , C07F9/553 , C07F9/576 , C07F9/645 , C07F9/6509
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06191
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公开(公告)号：EP0765330A1
公开(公告)日：1997-04-02
申请号：EP95922309.0
申请日：1995-06-13
CPC分类号： C07D499/00
摘要： The present invention is related to compounds which inhibit pancreatic cholesterol esterase. The compounds have formula (I), wherein R1 is H or C¿1-6? alkyl; R?2¿ is H or C¿1-6? alkyl; R?3¿ is H or C¿1-6? alkyl; X is CHR?6¿, S or O; R6 is H or C¿1-6? alkyl; R?4¿ is a hydrophobic moiety; and pharmaceutically acceptable salts thereof.
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公开(公告)号：EP0764167A1
公开(公告)日：1997-03-26
申请号：EP95923013.0
申请日：1995-06-08
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06191
摘要： Disclosed are compounds, compositions, and methods for inhibiting interleukin-1β protease activity, having formula (A), wherein Y = (a) or (b) or (c), Z = various bicyclic lactams with a bridgehead nitrogen.
摘要翻译： （A），其中Y =（a）或（b）或（c），Z =具有桥头氮的各种双环内酰胺，公开了抑制白细胞介素-1β蛋白酶活性的化合物，组合物和方法。
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公开(公告)号：EP0758891A1
公开(公告)日：1997-02-26
申请号：EP95918877.0
申请日：1995-04-28
发明人： DOLLE, Roland E. , RINKER, James M.
CPC分类号： C07C233/13 , C07C233/47 , C07C255/24 , C07C255/25 , C07C311/06
摘要： Disclosed are compounds, compositions and methods for inhibiting interleukin-1β protease activity, the compounds having formula (A) described herein.
摘要翻译： 公开了用于抑制白细胞介素-1β蛋白酶活性的化合物，组合物和方法，具有本文所述的式（A）的化合物。
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8.发明公开6-ARYL PYRAZOLO 3,4-d PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF 失效6 - 芳基 - 吡唑并（3,4-D）嘧啶-4- ONE，组合物和使用过程中FOR THEIR
公开(公告)号：EP0813534A1
公开(公告)日：1997-12-29
申请号：EP96907191
申请日：1996-03-05
申请人： SANOFI WINTHROP INC
发明人： BACON EDWARD R , SINGH BALDEV
IPC分类号： A61K31/505 , A61P9/00 , A61P9/12 , C07D487/04 , A61K31/535 , A61K31/54 , A61K31/55
CPC分类号： C07D487/04
摘要： 6-Aryl pyrazolo[3,4-d]pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or hypertension.
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9.发明公开SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO 3,4-b QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF 失效取代的N-环烷基甲基-1H-吡唑并3,4-B喹啉-4-胺和它们的组合物及其使用方法
公开(公告)号：EP0813533A1
公开(公告)日：1997-12-29
申请号：EP96910367
申请日：1996-03-05
申请人： SANOFI WINTHROP INC
发明人： KUMAR VIRENDRA , DORITY JOHN A JR
IPC分类号： A61K31/435 , A61P9/00 , A61P9/10 , A61P9/12 , C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance, and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.
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10.发明公开2-(2,3,5,6-TETRAFLUORO-4-PYRIDYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF 失效2-（2,3,5,6-四氟-4-吡啶基）-1,2,5- THIADIAZOLODIN-3-ON -1,1-二氧化物，手段及它们的使用方法
公开(公告)号：EP0792150A1
公开(公告)日：1997-09-03
申请号：EP95943624.0
申请日：1995-11-30
发明人： DESAI, Ranjit C.
CPC分类号： C07D417/04
摘要： 2-(2,3,5,6-Tetrafluoro-4-pyridyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides, pharmaceutical compositions containing them and methods for the treatment of degenerative diseases utilizing them.
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