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    HALOGENATED DIDEOXY SACCHARIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
    1.
    发明公开
    HALOGENATED DIDEOXY SACCHARIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF 有权
    HALOGENIER DIDEOXYSACCHARIDDERIVATE，HERSTELLUNGSVERFAHREN UND VERWENDUNG

    公开(公告)号：EP2520580A1

    公开(公告)日：2012-11-07

    申请号：EP10840284.3

    申请日：2010-07-26

    申请人： Suzhou Harmony Biotechnology Co., Ltd

    发明人： MAO, Hua

    IPC分类号： C07H5/02 ,  C07H13/06 ,  A61K31/7024 ,  A61K31/7048 ,  A61P35/00

    CPC分类号： C07H11/04 ,  C07D493/04 ,  C07H5/02

    摘要： The current invention is related to a halogenated dideoxy sugar derivative, wherein that the derivative has the following general structure I

    wherein X is halogen,

    or

    R 1 and R 2 are H or Br; R 3 and R 4 are OH or OAc. The compounds 1-14 of the current invention has strong inhibition effect on human nasopharyngeal cancer CNE-2Z cells, human lung cancer A549 cells. human colon cancer HT-29 cells, human liver cancer Bel-7402 cells, human rectum cancer cells HCE 8693, human stomach cancer BGC-803 cells, human esophagus cancer CaEs-17 cells, human breast cancer cells MCF-7, human ovarian cancer cells A2780, pancreatic cancer cells PC-3, human bladder cells EJ, human brain glia cells TG-905, human leukemia cells K562, human melanoma M 14 cells and human anaplastic thyroid carcinoma TA-K cells. They can be used to prepare anti-tumor medicament and have significant clinic value.

    摘要翻译： 本发明涉及卤代双脱氧糖衍生物，其中该衍生物具有以下一般结构I，其中X为卤素，或R 1和R 2为H或Br; R 3和R 4是OH或OAc。 本发明化合物1-14对人鼻咽癌CNE-2Z细胞，人肺癌A549细胞具有强烈的抑制作用。 人结肠癌HT-29细胞，人肝癌Bel-7402细胞，人直肠癌细胞HCE 8693，人胃癌BGC-803细胞，人食管癌CaEs-17细胞，人乳腺癌细胞MCF-7，人卵巢癌 细胞A2780，胰腺癌细胞PC-3，人膀胱细胞EJ，人脑胶质细胞TG-905，人白血病细胞K562，人黑素瘤M14细胞和人间变性甲状腺癌TA-K细胞。 它们可用于制备抗肿瘤药物，具有显着的临床价值。