公开(公告)号：EP1578723A3

公开(公告)日：2005-12-07

申请号：EP02807534.9

申请日：2002-10-17

申请人： Michigan State University ,  SYNTHON CORPORATION

发明人： HOLLINGSWORTH, Rawle, I. ,  WANG, Guijun ,  PADMAKUMAR, Raghavakaimal ,  MAO, Jianmin ,  ZHANG, Huiping ,  DAI, Zongmin ,  PUTHUPARAMPIL, Kanakamma

IPC分类号： C07D201/00

公开(公告)号：EP1578723A2

公开(公告)日：2005-09-28

申请号：EP02807534.9

申请日：2002-10-17

申请人： Michigan State University ,  SYNTHON CORPORATION

发明人： HOLLINGSWORTH, Rawle, I. ,  WANG, Guijun ,  PADMAKUMAR, Raghavakaimal ,  MAO, Jianmin ,  ZHANG, Huiping ,  DAI, Zongmin ,  PUTHUPARAMPIL, Kanakamma

IPC分类号： C07D201/00

CPC分类号： C40B40/04 ,  C07D263/20 ,  C07D263/24 ,  C07D413/12 ,  C07D417/12 ,  C12Q1/18 ,  C40B30/04 ,  C40B50/08 ,  G01N2333/31

摘要： A process for preparing N-(substituted)-C­- (substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C­- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl)­ oxazolidinones is described. The process can be used to produce combinatorial libraries of the above substituted oxazolidinones in a two or three step reaction comprising a plurality of reagents differing in numbers of carbons or particular substituted oxazolidinones. A number of substituted oxazolidinones produced using the above process have been discovered to have antimicrobial activity.