公开(公告)号：EP3039421A4

公开(公告)日：2017-04-05

申请号：EP14839238

申请日：2014-09-02

申请人： SANARIA INC ,  ANTIGEN DISCOVERY INC ,  THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES

发明人： FELGNER PHILIP ,  HOFFMAN STEPHEN L ,  SEDER ROBERT

IPC分类号： A61K39/015 ,  G01N33/68

CPC分类号： G01N33/6854 ,  A61K39/015 ,  G01N2333/445 ,  G01N2469/20

摘要： Disclosed herein are diagnostic assays for identifying individuals that are protected against Plasmodium falciparum caused malaria. Such assays are particularly useful for determining not only the protective efficacy of Pf whole parasite vaccines for individual subjects, but also within populations of vaccinated subjects. The assays comprise the use of proteomes representing at least 50% of Pf, preferably coupled to a solid phase as a fixed array. The arrays are used to probe the sera of human subjects, particularly subjects of human clinical trials of whole parasite malaria vaccines as well as public health vaccination campaigns. Serum samples with antibody profiles most strongly reactive in multiplex to CSP and MSP5 demonstrate a sensitivity of from 92% to 100% and a specificity of from 84% to 89%.

公开(公告)号：EP2387416A4

公开(公告)日：2012-09-12

申请号：EP10731974

申请日：2010-01-08

申请人： SANARIA INC

发明人： SIM B KIM LEE ,  LI MINGLIN ,  STAFFORD RICHARD E ,  HOFFMAN STEPHEN L

IPC分类号： A61K39/015

CPC分类号： A61K39/015 ,  A61K9/0019 ,  A61K31/4706 ,  A61K2039/522 ,  A61K2039/6081

摘要： Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites substantially separated from attendant non-sporozoite material, where the preparations of Plasmodium sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified Plasmodium sporozoites are likewise provided. Methods of purifying preparations of Plasmodium sporozoites are also provided.

摘要翻译： 公开了基本上纯化的疟原虫子孢子和与附带的非子孢子物质基本分离的疟原虫子孢子的制剂，其中疟原虫子孢子的制剂具有增加的纯度水平。 同样提供包含纯化的疟原虫子孢子的疫苗和药物组合物。 还提供了提纯疟原虫子孢子的制备方法。

公开(公告)号：EP2000026B1

公开(公告)日：2014-09-24

申请号：EP08013181.6

申请日：2003-04-07

申请人： Sanaria Inc.

发明人： Hoffman, Stephen L. ,  Luke, Thomas C.

IPC分类号： A01K67/033

CPC分类号： A01K67/033

公开(公告)号：EP1563301A4

公开(公告)日：2007-07-11

申请号：EP03789967

申请日：2003-11-20

申请人： SANARIA INC

发明人： HOFFMAN STEPHEN L ,  LUKE THOMAS C

IPC分类号： A61K20060101 ,  A61K39/00 ,  A61K39/002 ,  A61K39/015 ,  G01N33/536

CPC分类号： A61K39/015 ,  A61K2039/515

摘要： The invention comprises a novel method for protecting subjects against malaria. The method of the invention involves inoculation with attenuated sporozoites, and in particular, but not limited to subcutaneous, intramuscular, intradermal, mucosal, submucosal, and cutaneous administration.

公开(公告)号：EP1563301A2

公开(公告)日：2005-08-17

申请号：EP03789967.1

申请日：2003-11-20

申请人： Sanaria Inc.

发明人： HOFFMAN, Stephen, L ,  LUKE, Thomas, C

IPC分类号： G01N33/536

CPC分类号： A61K39/015 ,  A61K2039/515 ,  Y02A50/412

摘要： The invention comprises a novel method for protecting subjects against malaria. The method of the invention involves inoculation with attenuated sporozoites, and in particular, but not limited to subcutaneous, intramuscular, intradermal, mucosal, submucosal, and cutaneous administration.

公开(公告)号：EP3897986A2

公开(公告)日：2021-10-27

申请号：EP19926739.4

申请日：2019-12-17

申请人： SiO2 Medical Products, Inc. ,  Sanaria Inc.

发明人： HUNT, Benjamin ,  JACKSON, Chase Bryan ,  JAMES, Eric

IPC分类号： B01L3/00 ,  A01N1/02

公开(公告)号：EP3265815A2

公开(公告)日：2018-01-10

申请号：EP16759558.6

申请日：2016-03-04

申请人： Sanaria Inc. ,  Antigen Discovery Inc. ,  The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： FELGNER, Philip ,  HOFFMANN, Stephen L. ,  SEDER, Robert ,  CAMPO JR., Joseph J.

IPC分类号： G01N33/569 ,  G01N33/53 ,  G01N33/543 ,  G01N33/563 ,  C07K14/445

CPC分类号： G01N33/6854 ,  A61K39/015 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/54 ,  G01N33/56905 ,  G01N2333/445 ,  G01N2469/20 ,  Y02A50/412 ,  Y02A50/58

摘要： Disclosed herein are diagnostic methods and compositions for identifying individuals that are protected against Plasmodium falciparum caused malaria. Such methods are particularly useful for determining not only the protective efficacy of Pf whole parasite vaccines for individual subjects, but also within populations of vaccinated subjects. Also disclosed herein are subunit vaccines comprising at least one Pf immunologic determinant for protection against Plasmodium-caused malaria.

公开(公告)号：EP2956166A1

公开(公告)日：2015-12-23

申请号：EP14743724.8

申请日：2014-01-24

申请人： Sanaria Inc. ,  Academisch Ziekenhuis Leiden LUMC ,  Stichting Katholieke Universiteit

发明人： JANSE, Chris J. ,  ANNOURA, Takeshi ,  KHAN, Shahid M. ,  VAN SCHAIJK, Ben ,  PLOEMEN, Ivo HJ ,  VOS, Martijn W. ,  SAUERWEIN, Robert

IPC分类号： A61K39/015

CPC分类号： A61K39/015 ,  A61K2039/522 ,  A61K2039/545 ,  Y02A50/412

摘要： Disclosed herein are mutant Plasmodium-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage of Plasmodium development and the parasites do not reach the blood stage of development. Vaccines and pharmaceutical compositions comprising genetically attenuated Plasmodium sporozoites as well as methods of using the same are likewise provided.

摘要翻译： 本文公开了遗传减毒（GAP）的突变体疟原虫种寄生虫。 它们保留感染宿主的能力，侵袭宿主肝细胞，但随后其发育完全在疟原虫发育的肝脏阶段被捕获，寄生虫未达到血液发育阶段。 包含遗传减毒的疟原虫子孢子的疫苗和药物组合物以及其使用方法同样提供。

公开(公告)号：EP2000026A1

公开(公告)日：2008-12-10

申请号：EP08013181.6

申请日：2003-04-07

申请人： Sanaria Inc.

发明人： Hoffman, Stephen L. ,  Luke, Thomas C.

IPC分类号： A01K67/00 ,  C12N15/00 ,  A01M1/20 ,  A01K29/00

CPC分类号： A01K67/033

摘要： Disclosed are production of Plasmodium species sporozoites in Anopheles species mosquitoes, specifically; apparatuses and methods for the production of strains of haematophagous insects with desired properties such as hypoallergenicity or hyperinfectivity; methods of producing a parasite strain that is capable of withstanding cyropreservation at temperatures close to freezing; apparatuses and methods for the injection of an attenuated parasite vaccine; production of parasites and haematophagous insects that are free from contamination by unwanted biological agents.

摘要翻译： 披露了在按蚊种蚊子中生产疟原虫种子孢子; 用于生产具有期望性质如低致敏性或超感染性的血液昆虫菌株的装置和方法; 产生能够在接近冷冻的温度下耐受静脉储存的寄生虫菌株的方法; 用于注射减毒寄生虫疫苗的装置和方法; 产生不受不想要的生物制剂污染的寄生虫和血液昆虫。

公开(公告)号：EP3580235A1

公开(公告)日：2019-12-18

申请号：EP18707509.8

申请日：2018-02-12

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  Sanaria Inc.

发明人： FLYNN, Barbara ,  KISALU, Neville ,  SEDER, Robert ,  IDRIS, Azza ,  HOFFMAN, Stephen

IPC分类号： C07K16/20 ,  A61P33/06