公开(公告)号：EP3283128A1

公开(公告)日：2018-02-21

申请号：EP16756488.9

申请日：2016-02-26

申请人： Schmitthenner, Hans, F. ,  Sweeney-jones, Anne, M. ,  Williams, Scott

发明人： Schmitthenner, Hans, F. ,  Sweeney-jones, Anne, M. ,  Williams, Scott

IPC分类号： A61K51/04

CPC分类号： C07F5/00 ,  A61K51/082 ,  A61K51/088 ,  B01D15/3857 ,  B01D15/426 ,  C07F1/005 ,  C07F1/08 ,  C07F5/003

摘要： A process for the preparation of a radionuclide imaging agent includes providing an imaging agent including a chelated place-holder metal; loading the imaging agent onto an acid stable stationary phase; replacing the chelated place-holder metal of the imaging agent loaded on the stationary phase with a replacement radioactive metal under mild reaction conditions; and eluting the imaging agent including the chelated replacement radioactive metal from the stationary phase to provide a radionuclide imaging agent suitable for positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The imaging agent can include a targeting agent that is directly conjugated to the imaging agent or by means of a linker. The process may also apply to other metals that are non-radioactive but used as diluent metals or other metals that are strongly bound to DOTA.