公开(公告)号：EP2338078A1

公开(公告)日：2011-06-29

申请号：EP09792449.2

申请日：2009-09-11

申请人： Husher, Frederick Knute ,  Shum, Jee Jong

发明人： Husher, Frederick Knute ,  Shum, Jee Jong

IPC分类号： G02B21/34 ,  C10M113/16 ,  G01N33/552

CPC分类号： C03C17/30 ,  C03C17/3405 ,  C03C2217/75 ,  C03C2218/355 ,  G01N33/54353 ,  Y10T428/24612 ,  Y10T428/2852 ,  Y10T428/31612 ,  Y10T428/31663

摘要： A single layer multi-silane coating construct displays controlled covalent attachment between biological materials and microscope slide substrates. Choice of various silanation reagents and their mix ratios provides control over the overall hydrophilic/hydrophobic surface behavior, attachment site density, and reactive moiety type. Both two-dimensional (2d) and three-dimensional (3d) configurations use the same foundation basics. Improved biological adhesion and fluid flow during subsequent processing is achieved. The 3d configuration offers conformal adhesion for those tissue materials that are not monotonically flat as well as multiple point capture of protein/peptides.

摘要翻译： 单层多硅烷涂层构建体显示生物材料和显微镜载玻片基底之间的受控共价连接。 各种硅烷化试剂及其混合比例的选择提供了对总体亲水/疏水表面行为，附着位点密度和反应性部分类型的控制。 二维（2D）和三维（3D）配置都使用相同的基础基础知识。 在随后的加工过程中实现了改善的生物粘附和流体流动 3D配置为那些非单调扁平的组织材料以及蛋白质/肽的多点捕获提供了保形粘附。