公开(公告)号：EP2616084A1

公开(公告)日：2013-07-24

申请号：EP11788574.9

申请日：2011-10-10

申请人： Fernandez, Adrian, Hector, Antonio ,  Soubeiran, Chobet ,  Fernandez, Hector, Manuel

发明人： Fernandez, Adrian, Hector, Antonio ,  Soubeiran, Chobet ,  Fernandez, Hector, Manuel

IPC分类号： A61K33/24 ,  A61P33/00

CPC分类号： A61K33/245 ,  A61K9/06 ,  A61K31/29 ,  A61K31/618 ,  Y02A50/473

摘要： The present invention relates to the a bismuth-based composition, particularly involving the use of bismuth ions, particularly the Bi+3 ion, for prevention and/or treatment of the haemolytic uremic syndrome, with the invention also relating to the use of a bismuth ion in the manufacture of a medicament for the prevention and/or treatment of an infection caused by a Shiga-toxin producing Escherichia coli strain, as well as to a method for preventing and/or treating the haemolytic uremic syndrome comprising administering bismuth ions to a patient in need thereof, and a method for inhibiting dissemination of the gene encoding virulence factors of a Shiga-toxin producing Escherichia coli strain in animals and humans.

公开(公告)号：EP2616084B1

公开(公告)日：2015-08-05

申请号：EP11788574.9

申请日：2011-10-10

申请人： Fernandez, Adrian Hector Antonio ,  Soubeiran, Chobet ,  Fernandez, Hector Manuel

发明人： Fernandez, Adrian Hector Antonio ,  Soubeiran, Chobet ,  Fernandez, Hector Manuel

IPC分类号： A61K33/24 ,  A61P33/00

CPC分类号： A61K33/245 ,  A61K9/06 ,  A61K31/29 ,  A61K31/618 ,  Y02A50/473

摘要： The present invention relates to the a bismuth-based composition, particularly involving the use of bismuth ions, particularly the Bi+3 ion, for prevention and/or treatment of the haemolytic uremic syndrome, with the invention also relating to the use of a bismuth ion in the manufacture of a medicament for the prevention and/or treatment of an infection caused by a Shiga-toxin producing Escherichia coli strain, as well as to a method for preventing and/or treating the haemolytic uremic syndrome comprising administering bismuth ions to a patient in need thereof, and a method for inhibiting dissemination of the gene encoding virulence factors of a Shiga-toxin producing Escherichia coli strain in animals and humans.

摘要翻译： 本发明涉及一种铋基组合物，特别涉及使用铋离子，特别是Bi + 3离子来预防和/或治疗溶血性尿毒症综合征，本发明还涉及使用铋 制备用于预防和/或治疗由产生志贺毒素的大肠杆菌菌株引起的感染的药物的方法，以及用于预防和/或治疗溶血性尿毒症综合征的方法，其包括将铋离子施用于 需要的患者，以及抑制动物和人类中产生志贺毒素生产大肠杆菌菌株的编码毒力因子的基因的扩散的方法。