公开(公告)号：EP1070080A4

公开(公告)日：2004-12-29

申请号：EP99912266

申请日：1999-03-04

申请人： SMITHKLINE BEECHAM CORP ,  SB LABORATOIRES PHARMA ,  SMITHKLINE BEECHAM PLC ,  STADEL PAMELA

发明人： BERGSMA DERK J ,  CHAMBERS JONATHAN K ,  CHAN WINNIE ,  JOHNSON RANDALL K ,  KHANDOUDI NASSIRAH ,  LIVI GEORGE P ,  ROBERT PHILLIPPE ,  STADEL JEFFREY M ,  WILSON SHELAGH

IPC分类号： C12N15/09 ,  A61K45/00 ,  A61P9/04 ,  A61P9/06 ,  C07B61/00 ,  C07K1/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P21/06

CPC分类号： C07K14/705 ,  C07K14/723 ,  C40B40/00

公开(公告)号：EP1070080A1

公开(公告)日：2001-01-24

申请号：EP99912266.6

申请日：1999-03-04

申请人： SMITHKLINE BEECHAM CORPORATION ,  SB laboratoires Pharmaceutiques ,  SMITHKLINE BEECHAM PLC ,  Stadel, Pamela

发明人： BERGSMA, Derk, J. ,  CHAMBERS, Jonathan K.,Coldharbour Road ,  CHAN, Winnie ,  JOHNSON, Randall, K. ,  KHANDOUDI, Nassirah ,  LIVI, George, P. ,  ROBERT, Phillippe ,  STADEL, Jeffrey, M. ,  WILSON, Shelagh,Coldharbour Road

IPC分类号： C07H21/04 ,  C07K1/00 ,  C12P21/06 ,  C12N15/00 ,  C12N1/20

CPC分类号： C07K14/705 ,  C07K14/723 ,  C40B40/00

摘要： Human EDG-1c polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Human EDG-1c is identified as a selective receptor for sphingosine-1-phosphate ('S-1-P') and for dihydro S-1-P. Also disclosed are methods for discovering agonists and antagonists of the interaction between S-1-P and dihydro S-1-P and their cellular receptor, human EDG-1c, which may have utility in the treatment of several human diseases and disorders, including, but not limited to the treatment of infections such as bacterial, fungal, protozoan and viral infections.