公开(公告)号：EP3181556A4

公开(公告)日：2018-01-10

申请号：EP15831295

申请日：2015-08-13

Applicant: TECHNODERMA MEDICINES PTE LTD

Inventor： WANG ZENGQUAN ,  CAO SHELDON ,  MAO CHEN

IPC: C07D295/096 ,  A61K31/445 ,  A61K31/5375 ,  A61P3/04 ,  A61P17/14 ,  A61P19/10 ,  C07C239/22 ,  C07D209/44 ,  C07D217/04 ,  C07D241/04

CPC classification number: C07D295/096 ,  A61K8/42 ,  A61K31/445 ,  A61K31/5375 ,  A61Q7/00 ,  C07C239/22 ,  C07C259/06 ,  C07C315/04 ,  C07C317/22 ,  C07D209/44 ,  C07D211/14 ,  C07D211/46 ,  C07D211/52 ,  C07D217/04 ,  C07D241/04 ,  C07D241/08

Abstract: Provided is a small molecule compound as represented by structural formula (I). The product of the present invention in various concentrations and dosages can achieve an obvious change in the growth period of hairs, promoting the growth of the hairs, thus exhibiting an obvious effect of promoting hair growth. In addition, changes in the weight of a mouse in each group are slow, indicating that the test compound does not cause weight loss in an animal.

公开(公告)号：EP4050009A1

公开(公告)日：2022-08-31

申请号：EP20880211.6

申请日：2020-10-10

Applicant: Technoderma Medicines Pte Ltd

Inventor： XING, Li ,  LI, Guanqun ,  WANG, Xiaolei ,  CAI, Yuting ,  JIANG, Xiang ,  PAN, Xiang ,  ZHU, Wenhao ,  WANG, Yang ,  WANG, Zengquan

IPC: C07D403/14 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  A61P37/02 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P1/04 ,  A61P17/06

Abstract: Provided is a small molecule compound, which is characterized in having the structure represented by the following molecular formula: (I), wherein X1 and X2 are selected from carbon or nitrogen; G1 is a carbocyclic ring or heterocyclic ring having aromaticity; any one or more hydrogen atoms on the ring of G1 are substituted by R1; and R1 is selected from nitrogen-containing groups. The small molecule compound of the present invention can be used as a highly effective and specific JAK kinase inhibitor, specifically a Tyk2 inhibitor; and/or a JAK1 inhibitor, and/or a JAK1/Tyk2 or Tyk2/JAK1, Tyk2/Jak2 dual inhibitor.

公开(公告)号：EP3181556A1

公开(公告)日：2017-06-21

申请号：EP15831295

申请日：2015-08-13

Applicant: TECHNODERMA MEDICINES PTE LTD

Inventor： WANG ZENGQUAN ,  CAO SHELDON ,  MAO CHEN

IPC: C07D295/096 ,  A61K31/445 ,  A61K31/5375 ,  A61P3/04 ,  A61P17/14 ,  A61P19/10 ,  C07C239/22 ,  C07D209/44 ,  C07D217/04 ,  C07D241/04

CPC classification number: C07D295/096 ,  A61K8/42 ,  A61K31/445 ,  A61K31/5375 ,  A61Q7/00 ,  C07C239/22 ,  C07C259/06 ,  C07C315/04 ,  C07C317/22 ,  C07D209/44 ,  C07D211/14 ,  C07D211/46 ,  C07D211/52 ,  C07D217/04 ,  C07D241/04 ,  C07D241/08

Abstract: Provided is a small molecule compound as represented by structural formula (I). The product of the present invention in various concentrations and dosages can achieve an obvious change in the growth period of hairs, promoting the growth of the hairs, thus exhibiting an obvious effect of promoting hair growth. In addition, changes in the weight of a mouse in each group are slow, indicating that the test compound does not cause weight loss in an animal.

Abstract translation: 提供由结构式（I）表示的小分子化合物。 本发明的各种浓度和剂量的产品可以实现毛发生长期的明显变化，促进毛发的生长，从而显示促进毛发生长的明显效果。 此外，每组中小鼠的体重变化较慢，表明测试化合物在动物体内不会引起体重减轻。