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公开(公告)号：EP4446439A2
公开(公告)日：2024-10-16
申请号：EP24194139.2
申请日：2020-11-13
IPC分类号： C12Q1/70
摘要： The inventive technology includes novel systems, method and compositions for the identification and classification of host-derived RNA biomarkers produced in response to an infection.
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公开(公告)号：EP4400175A3
公开(公告)日：2024-09-25
申请号：EP24162513.6
申请日：2018-04-25
IPC分类号： C12N15/113 , A61K48/00 , C12N15/861 , C12N15/867 , C12N15/90 , A61K35/14 , A61P19/02 , A61P37/00 , A01K67/027
CPC分类号： C12N15/90 , C12N2310/2020170501 , A61K35/28 , A01K67/0275 , A61K48/00 , A01K2217/0520130101 , A01K2227/10520130101 , A01K2267/032520130101 , C12N2740/1604320130101 , A61K48/005 , A61P19/02 , A61P37/00 , C12N15/1138
摘要： Methods of preventing or treating rheumatoid arthritis (RA) in a subject by introducing the DRB1*04:01K71E mutation that is resistant to RA. The resistant allele is introduced into the subject having or at risk of developing RA, using a HLA CRISPR/Cas9 vector that targets codon 71 in the HLA allele DRB1*04:01, introducing a single A to G point mutation in codon 71 by homology directed repair to alter the lysine at position 71 of the expressed protein to glutamic acid. This modified allele is affected in the subject's hematopoietic stem cells, which are then expanded and transplanted back into the patient. This microgene therapy confers RA-resistance via an autologous transplant. The invention includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to modify the HLA DRB1*04:01 allele.
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公开(公告)号：EP4412643A1
公开(公告)日：2024-08-14
申请号：EP22879498.8
申请日：2022-10-06
CPC分类号： A61K39/39 , A61K9/5078 , A61K9/5089 , A61K9/501 , A61K2039/5550520130101 , A61K2039/5555520130101 , A61K39/00
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公开(公告)号：EP4412557A2
公开(公告)日：2024-08-14
申请号：EP22879153.9
申请日：2022-10-03
发明人： MATHIAS, Marc , LI, Kang , FLORES BELLVER, Miguel , APARICIO DOMINGO, Silvia , CHEN, Conan , CANTO-SOLER, Valeria
CPC分类号： A61B17/30 , A61B2017/30520130101 , A61F9/00727 , A61F2/0095
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公开(公告)号：EP4380967A1
公开(公告)日：2024-06-12
申请号：EP22786137.4
申请日：2022-08-04
发明人： KOHLER, Mark , DANIS, Catherine , FRY, Terry J. , LEACH, Lillie
IPC分类号： C07K14/725 , A61P35/00 , C12N5/10 , C12N5/0783
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7.发明公开
公开(公告)号：EP4326904A2
公开(公告)日：2024-02-28
申请号：EP22812081.2
申请日：2022-05-25
申请人： The Regents of the University of Colorado, a body corporate , MUSC Foundation for Research Development
IPC分类号： C12Q1/6883 , A61P25/32
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公开(公告)号：EP4312946A1
公开(公告)日：2024-02-07
申请号：EP22782202.0
申请日：2022-03-31
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公开(公告)号：EP4245257A2
公开(公告)日：2023-09-20
申请号：EP23176513.2
申请日：2014-05-12
IPC分类号： A61F2/16
摘要： A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary component for stability. Such attachment may include actuatable interlocking members.
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公开(公告)号：EP4236868A1
公开(公告)日：2023-09-06
申请号：EP21887544.1
申请日：2021-10-28
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