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公开(公告)号：EP2295492A1
公开(公告)日：2011-03-16
申请号：EP09011669.0
申请日：2009-09-11
发明人： Huang, Ching-Tzer
IPC分类号： C08K5/17
摘要： The present invention relates to glycine derivatives as additive for an aqueous polyurethane dispersion. Said glycine derivatives can increase the fluidity of aqueous polyurethane dispersion and therefore is useful for preparation of aqueous polyurethane dispersion with high solid content. Besides, the glycine derivatives are able to significantly decrease the viscosity of aqueous polyurethane dispersion; therefore, the aqueous polyurethane dispersion with high solid content can be stored stably.
摘要翻译： 本发明涉及作为水性聚氨酯分散体的添加剂的甘氨酸衍生物。 所述甘氨酸衍生物可以增加水性聚氨酯分散体的流动性，因此可用于制备具有高固含量的水性聚氨酯分散体。 此外，甘氨酸衍生物能够显着降低水性聚氨酯分散体的粘度; 因此，可以稳定地储存高固含量的水性聚氨酯分散体。
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2.发明授权Refillable sheet dispenser with flexibility in accommodating stacked note sheets 有权可再填充的片材分配器具有堆叠信纸的柔性住宿
公开(公告)号：EP1990209B1
公开(公告)日：2009-08-12
申请号：EP07251918.4
申请日：2007-05-09
发明人： Kuo, Tsung-Tien , Liu, Jen-Rong , Ho, Shu-Wei
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3.发明公开
公开(公告)号：EP3085390A1
公开(公告)日：2016-10-26
申请号：EP16166010.5
申请日：2016-04-19
发明人： Tsao, Ning , Hsu, Chih-Wei
摘要： The disclosure provides a compound comprising bisphosphonate functional group and chelating agent. The bisphosphonate functional group part has high affinity for bone tissue, and the chelating agent part has high affinity for metal tracer such as radioisotope. The disclosed compound could be rapidly adsorbed onto the bone surface, and could steady emit ionizing radiation. Therefore, the disclosed compound is suitable for bone scanning technology to find abnormalities in bone.
摘要翻译： 本公开提供了包含双膦酸盐官能团和螯合剂的化合物。 双膦酸官能团部分对骨组织具有高亲和力，螯合剂部分对金属示踪剂如放射性同位素具有高亲和力。 所公开的化合物可以快速吸附到骨表面上，并且可以稳定地发射电离辐射。 因此，所公开的化合物适用于骨扫描技术以发现骨骼异常。
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4.发明公开Metal-polysaccharide conjugates: compositions and synthesis 有权Metallpolysaccharid-Verbundstoffe Zusammensetzungen und Synthese
公开(公告)号：EP2014306A3
公开(公告)日：2012-08-15
申请号：EP08009119.2
申请日：2008-05-16
发明人： Wei, I-Chien , Yang, David J. , Yu, Dong-Fang
IPC分类号： A61K47/48
CPC分类号： A61K47/4823 , A61K31/282 , A61K33/24 , A61K47/61
摘要： The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a monomeric amino acid having an O-group to a polysaccharide and by conjugating a metal to the O-group to form a polysaccharide conjugate. According to a third embodiment, the disclosure relates to a method of killing a cancer cell by administering to the cell an effective amount of a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid.
摘要翻译： 在一个实施方案中，本发明包括多糖缀合物。 该缀合物具有多糖和至少一种与多糖共价结合的O-基团的单体氨基酸。 缀合物还具有至少一种由氨基酸的O-基缀合的金属。 根据另一个实施方案，本公开提供了通过将具有O-基团的单体氨基酸共价键合到多糖并通过将金属与O基团缀合以形成多糖缀合物来合成多糖缀合物的方法。 根据第三实施方案，本公开涉及通过向细胞施用有效量的多糖缀合物来杀死癌细胞的方法。 该缀合物具有多糖和至少一种与多糖共价结合的O-基团的单体氨基酸。 缀合物还具有至少一种由氨基酸的O-基缀合的金属。
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公开(公告)号：EP3085390B1
公开(公告)日：2020-02-26
申请号：EP16166010.5
申请日：2016-04-19
发明人： Tsao, Ning , Hsu, Chih-Wei
IPC分类号： A61K51/04 , C07F9/38 , C07F9/40 , C07F9/6524 , A61K103/10
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公开(公告)号：EP1533133A1
公开(公告)日：2005-05-25
申请号：EP03257269.5
申请日：2003-11-18
发明人： Kuo, Tsung-Tien , Liu, Jen-Rong , Tsai, Chin-Chung
CPC分类号： B42D15/008 , B42D5/042 , Y10T428/14
摘要： A memo sheet 3 includes a sheet member 31 having opposite front and back sides 311, 312, a fold line 32 dividing the sheet member 31 into cover and hidden parts 313, 314, and a removable pressure sensitive adhesive layer 33. Each of the cover and hidden parts 313, 314 has a marking face 315, 316 arranged at the front side 311 of the sheet member 31, and a back face 317, 318 arranged at the back side 312 of the sheet member 31. The adhesive layer 33 is provided on the back face 318 of the hidden part 314. The sheet member 31 is foldable along the fold line 32 to adhere the back face 318 of the hidden part 314 over the back face 317 of the cover part 313 through the adhesive layer 33 so that the marking face 316 of the hidden part 314 is placed opposite to the marking face 315 of the cover part 313.
摘要翻译： 备注片3包括具有相对的前侧和后侧311,312的片材构件31，将片构件31分成盖和隐藏部313,314的折叠线32和可移除的压敏粘合剂层33.每个盖 并且隐藏部313,314具有布置在片构件31的前侧311处的标记面315,316和布置在片构件31的后侧312的背面317,318。提供粘合层33 在隐藏部分314的背面318上。薄片构件31可沿着折叠线32折叠，以通过粘合剂层33将隐藏部分314的背面318粘合在覆盖部分313的背面317上，使得 隐藏部分314的标记面316被放置成与盖部分313的标记面315相对。<图像>
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公开(公告)号：EP1698351B1
公开(公告)日：2017-06-07
申请号：EP06004026.8
申请日：2006-02-28
发明人： Wei, I-Chien , Yang, David J. , Yu, Dong-Fang
IPC分类号： A61K51/08 , A61K31/505 , A61K31/66
CPC分类号： A61K31/505 , A61K31/66 , A61K51/025
摘要： The invention includes glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.
摘要翻译： 本发明包括具有糖苷和通过酰胺键共价结合的肽的糖肽。 糖肽还可以包括与糖肽结合的诊断或治疗剂。 诸如放射性核素的金属也可以与糖肽螯合。 本发明的具体实施方案涉及由聚（氨基酸）如聚（谷氨酸）或聚（天冬氨酸）共价结合的脱乙酰壳多糖制成的糖肽。 与糖肽缀合的诊断剂可以促进成像。 可以与糖肽结合的具体治疗剂包括抗癌药物，类风湿关节炎药物，抗凝血剂，抗血管生成药物，凋亡药物，骨质疏松症药物，类固醇和抗炎药物。 一些药剂如放射性核素可能具有诊断和治疗作用。 糖肽可以通过在碳二亚胺和酸基活化剂的存在下结合糖苷和肽来在糖苷和肽之间形成酰胺键来制备。
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公开(公告)号：EP1698351A3
公开(公告)日：2006-12-27
申请号：EP06004026.8
申请日：2006-02-28
发明人： Wei, I-Chien , Yang, David J. , Yu, Dong-Fang
IPC分类号： A61K51/08 , A61K31/505 , A61K31/66
CPC分类号： A61K31/505 , A61K31/66 , A61K51/025
摘要： The invention includes glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.
摘要翻译： 本发明包括具有糖苷和通过酰胺键共价结合的肽的糖肽。 糖肽还可以包括与糖肽结合的诊断或治疗剂。 诸如放射性核素的金属也可以与糖肽螯合。 本发明的具体实施方案涉及由聚（氨基酸）如聚（谷氨酸）或聚（天冬氨酸）共价结合的脱乙酰壳多糖制成的糖肽。 与糖肽缀合的诊断剂可以促进成像。 可以与糖肽结合的具体治疗剂包括抗癌药物，类风湿关节炎药物，抗凝血剂，抗血管生成药物，凋亡药物，骨质疏松症药物，类固醇和抗炎药物。 一些药剂如放射性核素可能具有诊断和治疗作用。 糖肽可以通过在碳二亚胺和酸基活化剂的存在下结合糖苷和肽来在糖苷和肽之间形成酰胺键来制备。
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9.发明公开Chemically modified polyaminosaccharide by a hydrocarbyl sultone compound 审中-公开Mit Hydrocarbyl-Sultone化学改性Polyaminosaccharid
公开(公告)号：EP1607406A1
公开(公告)日：2005-12-21
申请号：EP05291299.5
申请日：2005-06-17
发明人： Wei, I-Chien , Lee, Kung-Hsing , Hung, Hsien-Ming , Tsao, Ning , Hsu, Meng-Hui, 4F, No. 6, Alley 3, Lane 148 , Lin, Shan-Ying , Huang, Ya-Hui
CPC分类号： A61K8/736 , A61K2800/75 , A61L15/28 , A61Q17/04 , A61Q19/00 , A61Q19/007 , C08B37/003 , C08L5/08
摘要： This invention discloses chemically modified polyaminosaccharides, in particular chemically modified chitosans, in the molecular structure of which a predetermined proportion of the amino functional groups is sulfonated by the hydrocarbyl sultone compound via a covalent bond. Such chemically modified polyaminosaccharides may be produced by a process of sulfonating an un-modified polyaminosaccharide having amino functional groups by a hydrocarbyl sultone compound in the presence of an organic solvent under a suitable temperature. Chemically modified chitosans of this invention may be used in a variety of applications, including wound healing.
摘要翻译： 本发明公开了其分子结构中化学修饰的多氨糖，特别是化学修饰的壳聚糖，其中预定比例的氨基官能团被烃基磺内酯化合物经共价键磺化。 这种化学修饰的多氨糖可以通过在合适的温度下在有机溶剂的存在下通过烃基磺内酯化合物磺化未改性的具有氨基官能团的多氨基糖的方法来制备。 本发明的化学修饰的壳聚糖可用于各种应用，包括伤口愈合。
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10.发明授权Metal-polysaccharide conjugates: compositions and synthesis 有权金属多糖 - 共轭物：Zusammensetzungen und Synthese
公开(公告)号：EP2014306B1
公开(公告)日：2015-02-25
申请号：EP08009119.2
申请日：2008-05-16
发明人： Wei, I-Chien , Yang, David J. , Yu, Dong-Fang
IPC分类号： A61K47/48
CPC分类号： A61K47/4823 , A61K31/282 , A61K33/24 , A61K47/61
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