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公开(公告)号：EP4374928A3
公开(公告)日：2024-08-14
申请号：EP24155493.0
申请日：2018-04-26
申请人： The Brigham And Women's Hospital Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： YU, Paul B. , HUANG, Wenwei , SANDERSON, Paul B. , JIANG, Jian-kang , SHAMIM, Khalida , ZHENG, Wei , HUANG, Xiuli , TAWA, Gregory , LEE, Arthur , ALIMARDANOV, Asaf , HUANG, Junfeng
IPC分类号： C07D487/04 , C07D471/04 , C07D519/00 , A61K31/519 , A61K31/4375 , A61K31/438 , A61K31/439 , A61K31/4365 , A61K31/4355 , A61P19/08 , A61P19/02 , A61P35/00 , A61P35/04 , A61P37/00 , A61P43/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61P35/04 , A61P35/00 , A61P37/00 , A61P19/02 , A61P43/00 , A61P19/08 , A61K45/06
摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).
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公开(公告)号：EP4340888A1
公开(公告)日：2024-03-27
申请号：EP22805497.9
申请日：2022-05-19
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公开(公告)号：EP4273165A2
公开(公告)日：2023-11-08
申请号：EP23177086.8
申请日：2017-04-28
发明人： GULLA, Stefano V. , HUARD, Christine , BUHLMANN, Janet Elizabeth , ALMAGRO, Juan Carlos , KODANGATTIL, Sreekumar R. , GREENBERG, Steven A. , LAVALLIE, Edward Roland , BENNETT, Eric M. , MOSYAK, Lidia , HALL, James Perry , COYLE, Anthony John
IPC分类号： C07K16/24
摘要： The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes.
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公开(公告)号：EP4233697A3
公开(公告)日：2023-09-27
申请号：EP23178946.2
申请日：2019-06-19
发明人： BHAVSAR, Sonya Sanat , JOSEPHY, Noam , EDELMAN, Elazer R. , CHANG, Brian Yale , KELLER, Steven , EL KATERJI, Ahmad , TAN, Qing , MOYER, Christian , SHIP, Alexander
IPC分类号： A61B5/02 , A61B5/0215 , A61B5/029 , A61B5/021 , A61B5/00 , A61M60/13 , A61M60/216 , A61M60/411 , A61M60/515 , A61M60/531 , A61M60/538 , A61M60/523
摘要： The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.
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公开(公告)号：EP4242655A2
公开(公告)日：2023-09-13
申请号：EP23163877.6
申请日：2006-06-08
申请人： Dana-Farber Cancer Institute, Inc. , The Brigham and Women's Hospital, Inc. , Emory University , The President and Fellows of Harvard College
发明人： Barber, Daniel , Wherry, John E. , Freeman, Gordan , Sharpe, Arlene , Dorfman, David M. , Ahmed, Rafi
IPC分类号： G01N33/53
摘要： The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
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公开(公告)号：EP4192567A1
公开(公告)日：2023-06-14
申请号：EP21758665.0
申请日：2021-08-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , Novo Nordisk A/S , The Brigham And Women's Hospital Inc.
发明人： ARRICK, Graham , BOHR, Adam , CLEVELAND, Cody , FRANDSEN, Kim , GHAZAL, Aghiad , GWYNNE, Declan , JEPSEN, Jacob Pyung Hwa , KOZHUHAROV, Bozhidar Nikolaev , LANGER, Robert , LAST, Torben Sebastian , LU, Yi , MOURIDSEN, Brian , ROXHED, Niclas , STICKER, Drago , TRAVERSO, Carlo Giovanni , WAINER, Jacob , WATER, Jorrit Jeroen , YOU, Siheng S
IPC分类号： A61M31/00
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公开(公告)号：EP4061209A1
公开(公告)日：2022-09-28
申请号：EP20890849.1
申请日：2020-11-23
发明人： GORMLEY, William, B. , TOKUDA, Junichi , ROBERTSON, Faith, C. , PRIETO, Paola, Calvachi , KING, Franklin , PIPER, Steve
IPC分类号： A61B5/05
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公开(公告)号：EP4012024A1
公开(公告)日：2022-06-15
申请号：EP21193478.1
申请日：2015-12-29
发明人： SACKSTEIN, Robert
IPC分类号： C12N5/0797 , C12N5/078 , C12N5/0783 , C12N5/0784 , C12N5/077 , A61K35/12
摘要： Methods of treatment are provided herein, including administration of a population cells modified to enforce expression of an E-selectin and/or an L-selectin ligand, the modified cell population having a cell viability of at least 70% after a treatment to enforce such expression.
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公开(公告)号：EP3981438A1
公开(公告)日：2022-04-13
申请号：EP21197262.5
申请日：2016-05-04
摘要： Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides a second generation oncolytic virus rQNestin34.5v2 with less toxicity that is more effective at selective killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic virus described herein is suitable for treatment of glioblastoma, as well as other cancers.
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