公开(公告)号：EP3201187A1

公开(公告)日：2017-08-09

申请号：EP15846595.5

申请日：2015-10-01

申请人： The Brigham and Women's Hospital, Inc. ,  The United States of America, as represented by the secretary, Department of Health and Human Services ,  University of Houston System

发明人： YU, Paul B. ,  CUNY, Gregory D. ,  MOHEDAS, Agustin H. ,  LEE, Arthur

IPC分类号： C07D401/14 ,  C07D417/14 ,  C07D221/22 ,  C07D403/02 ,  A61K31/551 ,  C07D213/02 ,  C07D401/04 ,  C07D409/04 ,  A61K31/44

CPC分类号： C07D401/14 ,  A61K31/44 ,  A61K31/551 ,  A61P3/00 ,  A61P5/00 ,  A61P9/00 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  C07D213/02 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/74 ,  C07D221/22 ,  C07D401/04 ,  C07D403/02 ,  C07D405/04 ,  C07D409/04 ,  C07D417/14 ,  C07D487/04

摘要： The present invention provides small molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

摘要翻译： 本发明提供BMP信号传导的小分子抑制剂和用于抑制BMP信号传导的组合物和方法。 这些化合物和组合物可用于调节细胞生长，分化，增殖和凋亡，因此可用于治疗与BMP信号传导相关的疾病或病症，包括炎症，心血管疾病，血液病，癌症和骨疾病，如 以及调节细胞分化和/或增殖。 这些化合物和组合物还可用于降低ApoB-100或LDL的循环水平并治疗或预防获得性或先天性高胆固醇血症或高脂蛋白血症; 与脂质吸收或代谢缺陷相关的疾病，病症或综合征; 或由高脂血症引起的疾病，病症或综合征。

公开(公告)号：EP4374928A2

公开(公告)日：2024-05-29

申请号：EP24155493.0

申请日：2018-04-26

申请人： The Brigham And Women's Hospital Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： YU, Paul B. ,  HUANG, Wenwei ,  SANDERSON, Paul B. ,  JIANG, Jian-kang ,  SHAMIM, Khalida ,  ZHENG, Wei ,  HUANG, Xiuli ,  TAWA, Gregory ,  LEE, Arthur ,  ALIMARDANOV, Asaf ,  HUANG, Junfeng

IPC分类号： A61P43/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61P35/04 ,  A61P35/00 ,  A61P37/00 ,  A61P19/02 ,  A61P43/00 ,  A61P19/08 ,  A61K45/06

摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

公开(公告)号：EP4374928A3

公开(公告)日：2024-08-14

申请号：EP24155493.0

申请日：2018-04-26

申请人： The Brigham And Women's Hospital Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： YU, Paul B. ,  HUANG, Wenwei ,  SANDERSON, Paul B. ,  JIANG, Jian-kang ,  SHAMIM, Khalida ,  ZHENG, Wei ,  HUANG, Xiuli ,  TAWA, Gregory ,  LEE, Arthur ,  ALIMARDANOV, Asaf ,  HUANG, Junfeng

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00 ,  A61K31/519 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/439 ,  A61K31/4365 ,  A61K31/4355 ,  A61P19/08 ,  A61P19/02 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P43/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61P35/04 ,  A61P35/00 ,  A61P37/00 ,  A61P19/02 ,  A61P43/00 ,  A61P19/08 ,  A61K45/06

摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

公开(公告)号：EP2970311A2

公开(公告)日：2016-01-20

申请号：EP14775808.0

申请日：2014-03-13

申请人： The Brigham and Women's Hospital, Inc. ,  The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： ALIMARDANOV, Asaf ,  CUNY, Gregory, D. ,  GREWAL, Gurmit, Singh ,  LEE, Arthur ,  MCKEW, John, C. ,  MOHEDAS, Agustin, H. ,  SHEN, Min ,  XU, Xin ,  YU, Paul, B.

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61P9/10 ,  A61P35/00 ,  A61P31/10 ,  A61P27/00 ,  A61P29/00 ,  A61P33/00 ,  A61P31/04 ,  A61P31/12 ,  A61P5/30

CPC分类号： C07D487/04 ,  C07D519/00

摘要： The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

摘要翻译： 本发明提供了BMP信号传导的小分子抑制剂。 这些化合物可用于调节细胞生长，分化，增殖和凋亡，因此可用于治疗与BMP信号传导相关的疾病或病症，包括炎症，心血管疾病，血液病，癌症和骨疾病，以及 用于调节细胞分化和/或增殖。 这些化合物还可用于降低ApoB-100或LDL的循环水平，并治疗或预防获得性或先天性高胆固醇血症或高脂蛋白血症; 与脂质吸收或代谢缺陷相关的疾病，病症或综合征; 或由高脂血症引起的疾病，病症或综合征。

公开(公告)号：EP3615538A1

公开(公告)日：2020-03-04

申请号：EP18790880.1

申请日：2018-04-26

申请人： The Brigham and Women's Hospital, Inc. ,  The United States of America, as Represented by The Department of Health and Human Services

发明人： YU, Paul, B. ,  HUANG, Wenwei ,  SANDERSON, Philip, Edward ,  JIANG, Jian-kang ,  SHAMIM, Khalida ,  ZHENG, Wei ,  HUANG, Xiuli ,  TAWA, Gregory ,  LEE, Arthur ,  ALIMARDANOV, Asaf ,  HUANG, Junfeng

IPC分类号： C07D487/04 ,  C07D487/08 ,  C07D471/10 ,  C07D471/04 ,  C07D487/00 ,  C07D487/10 ,  C07D495/04 ,  C07D491/056 ,  C07D519/00 ,  A61K31/519 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/439 ,  A61K31/4365 ,  A61K31/4355 ,  A61P19/08 ,  A61P19/02 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P43/00