公开(公告)号：EP2300823A2

公开(公告)日：2011-03-30

申请号：EP09771053.7

申请日：2009-06-25

申请人： Baylor Research Institute ,  The National Institute For Medical Research ,  Imperial College Healthcare NHS Trust

发明人： BANCHEREAU, Jacques, F. ,  CHAUSSABEL, Damien ,  O'GARRA, Anne ,  BERRY, Matthew ,  KON, Onn, Min

IPC分类号： G01N33/50 ,  G01N33/53 ,  C12Q1/00

CPC分类号： G01N33/5695 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2800/60

摘要： The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non- infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection.