公开(公告)号：EP3683312A3

公开(公告)日：2020-09-16

申请号：EP19208141.2

申请日：2014-04-23

申请人： The University Court of The University of Aberdeen

发明人： BARELLE, Caroline Jane ,  FINLAY, William James Jonathan ,  DARMANIN-SHEEHAN, Alfredo ,  PORTER, Andrew Justin Radcliffe

IPC分类号： C12N15/13 ,  C07K16/00 ,  C07K16/18

摘要： The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I):

         FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4

comprising (1) isolating RNA from a member of a species in the Elasmobranchii subclass; (2) amplifying DNA sequences from RNA obtained; (3) selecting a DNA sequence from the database prepared; (4) amplifying DNA sequences encoding two or more contiguous peptide domains of FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4; (5) ligating together said amplified DNA sequences to form DNA sequences encoding an antigen specific binding molecule; (6) cloning the amplified DNA obtained into a display vector; and (7) transforming a host with said display vector to produce a library of said antigen specific antigen binding molecules. The invention also provides methods for the production of an antigen specific antigen binding molecule as defined, pharmaceutical compositions comprising such molecules and uses thereof in medicine.

公开(公告)号：EP2989204B1

公开(公告)日：2019-03-20

申请号：EP14720559.5

申请日：2014-04-23

申请人： The University Court of The University of Aberdeen

发明人： BARELLE, Caroline Jane ,  FINLAY, William James Jonathan ,  DARMANIN-SHEEHAN, Alfredo

IPC分类号： C12N15/13 ,  C07K16/00 ,  C07K16/18

公开(公告)号：EP3265485A1

公开(公告)日：2018-01-10

申请号：EP16710485.0

申请日：2016-03-04

申请人： The University Court of The University of Aberdeen

发明人： GOW, Neil, Andrew, Robert ,  RUDKIN, Fiona, Marion ,  ERWIG, Lars-Peter ,  JENSEN, Allan

IPC分类号： C07K16/14 ,  G01N33/53

CPC分类号： C07K16/14 ,  A61K39/39575 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/56961 ,  G01N2333/40 ,  G01N2469/10

摘要： This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgG1 mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.

公开(公告)号：EP3215608A1

公开(公告)日：2017-09-13

申请号：EP15797885.9

申请日：2015-11-04

申请人： The University Court of The University of Aberdeen ,  University Court of The University of St Andrews

发明人： NAISMITH, James ,  KOEHNKE, Jesko ,  BENT, Andrew ,  WESTWOOD, Nicholas ,  MANN, Greg ,  HOUSSEN IBRAHIM, Wael ,  JASPARS, Marcel

IPC分类号： C12N9/00

CPC分类号： C07K1/107 ,  C12N9/90 ,  C12P21/02 ,  C12Y504/99027

摘要： This invention relates to an engineered leader-independent heterocyclase (also known as a cyclodehydratase) comprising a defined cyanobactin leader sequence which drives the efficient conversion of heterocyclisable amino acids, such as Ser, Thr and Cys, within a peptide substrate lacking a leader sequence into heterocycles produce a homogenous heterocycle-containing product. This may be useful in biotechnology and chemical synthesis.

摘要翻译： 本发明涉及工程改造的前导独立的杂环酶（也称为环水解酶），其包含限定的氰基杆菌蛋白前导序列，其驱动缺乏前导序列的肽底物内的可杂环氨基酸例如Ser，Thr和Cys的有效转化成 杂环产生均质的含杂环的产物。 这可能对生物技术和化学合成有用。

公开(公告)号：EP2137141B1

公开(公告)日：2015-12-02

申请号：EP08718826.4

申请日：2008-03-20

申请人： The University Court of The University of Aberdeen

发明人： GREIG, Iain, Robert ,  VAN'T HOF, Robert, Jurgen ,  RALSTON, Stuart, Hamilton

IPC分类号： C07C311/21 ,  A61K31/18 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P29/00 ,  C07C311/44 ,  C07C311/46 ,  C07C317/14

CPC分类号： C07C311/21 ,  C07C311/44 ,  C07C311/46 ,  C07C317/14

公开(公告)号：EP2120992B1

公开(公告)日：2013-03-27

申请号：EP08701599.6

申请日：2008-01-18

申请人： The University Court of The University of Aberdeen ,  THE COMMON SERVICES AGENCY FOR THE SCOTTISH HEALTH SERVICE

发明人： URBANIAK, Stanislaw Joseph ,  BARKER, Robert Norman ,  SUKATI, Hosea

IPC分类号： A61K39/00 ,  A61K38/17 ,  A61K38/10

CPC分类号： A61K39/0008 ,  A61K38/177

公开(公告)号：EP1448995B9

公开(公告)日：2011-10-12

申请号：EP02779724.0

申请日：2002-11-20

申请人： The University Court of The University of Aberdeen

发明人： Kelly, Denise

IPC分类号： G01N33/68 ,  G01N33/564 ,  A61K31/02 ,  A61P1/00 ,  A61P29/00 ,  A61P37/00 ,  A61K35/74

CPC分类号： G01N33/6863 ,  A61K31/02 ,  A61K35/74 ,  G01N33/6872 ,  G01N2333/4703 ,  G01N2500/00

摘要： The invention relates to an assay to select a candidate drug for the treatment of inflammatory disease due to cytokine production. The assay comprises: a) exposing said candidate drug to intestinal cells; and b) analysing the effect of the said candidate drug selected from the group consisting of the variation of nuclear export or import of transcription factors from the NF-&kgr;B family the disruption of transcriptional activity of transcription factors from the NF-&kgr;B family, the differential histone acetylation of p65 (RelA); the variation of the amount of PPARγ/RelA complexes in the cytosol of the cells; and a combination thereof. The invention further relates to methods for the treatment of inflammatory cytokine production associated diseases and to the use of a therapeutically effective dose of Bacteroides thetaiotaomicron or a component thereof.

公开(公告)号：EP1897546B1

公开(公告)日：2010-10-27

申请号：EP07008956.0

申请日：2000-02-01

申请人： AstraZeneca AB ,  The University Court of The University of Aberdeen

发明人： Cameron, Norman Eugene ,  Cotter, Mary Anne

IPC分类号： A61K31/505 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/401 ,  A61P43/00

CPC分类号： A61K31/505 ,  Y10S514/866

公开(公告)号：EP1602140B1

公开(公告)日：2010-06-30

申请号：EP04715397.8

申请日：2004-02-27

申请人： The University Court of The University of Aberdeen

发明人： MACPHEE, Donald, Elliott

IPC分类号： H01M8/06 ,  H01M14/00 ,  H01M8/10 ,  B01J19/24 ,  B01J19/12

CPC分类号： H01M14/005 ,  H01M8/0606 ,  H01M8/1009 ,  H01M8/16 ,  Y02E60/527

公开(公告)号：EP2007204A2

公开(公告)日：2008-12-31

申请号：EP07712821.3

申请日：2007-03-02

申请人： The University Court of The University of Aberdeen ,  Rothamsted Research Limited ,  Pickett, John Anthony ,  Logan, James, George ,  Birkett, Michael Alexander ,  Mordue, Anne Jennifer

发明人： PICKETT, John, Anthony ,  LOGAN, James, George ,  BIRKETT, Michael, Alexander ,  MORDUE, Anne, Jennifer

IPC分类号： A01N49/00 ,  A01N35/02 ,  A01P17/00

CPC分类号： A01N49/00 ,  A01N35/02 ,  A01N2300/00

摘要： The present invention provides compositions for inhibiting the activity of an insect pest against a subject (or repelling an insect pest from an environment or preventing attraction to an environment) which compositions comprise geranylacetone as an active ingredient plus a carrier plus a further active ingredient selected from the list consisting of: 6-Methyl-hepten-2-one, octanal, plus optional other chemicals. Also provided are related materials and methods of use.