公开(公告)号：EP3442942A1

公开(公告)日：2019-02-20

申请号：EP17781660.0

申请日：2017-04-18

申请人： British Columbia Cancer Agency Branch ,  The University of British Columbia University-Industry Liaison Office

发明人： ANDERSEN, Raymond ,  SADAR, Marianne Dorothy ,  JlAN, Kunzhong ,  MAWJl, Nasrin R. ,  WANG, Jun ,  BANUELOS, Carmen Adriana ,  YANG, Yu-Chi

IPC分类号： C07C317/16 ,  A61K31/09 ,  A61K31/10 ,  A61K31/165 ,  A61K31/222 ,  A61K31/4164 ,  A61P35/00 ,  C07C311/04 ,  C07C317/22 ,  C07C43/23 ,  C07D233/60 ,  C07D295/088

公开(公告)号：EP3245193A1

公开(公告)日：2017-11-22

申请号：EP16736999.0

申请日：2016-01-13

申请人： British Columbia Cancer Agency Branch ,  The University of British Columbia University-Industry Liaison Office

发明人： SADAR, Marianne Dorothy ,  MAWJI, Nasrin R. ,  BANUELOS, Carmen Adriana ,  ANDERSEN, Raymond John ,  FERNANDEZ, Javier Garcia ,  JIAN, Kunzhong

IPC分类号： C07D249/04 ,  A61K31/4164 ,  A61K31/4192 ,  A61K31/495 ,  A61K51/04 ,  A61P35/00 ,  C07D233/64 ,  C07D295/088

CPC分类号： A61K45/06 ,  A61K31/4164 ,  A61K31/4192 ,  A61K31/5375 ,  A61K51/0453 ,  A61K51/0459 ,  A61K51/0463 ,  A61K51/0465 ,  A61P35/00 ,  C07B59/002 ,  C07D233/60 ,  C07D249/04 ,  C07D265/30 ,  C07D295/088

摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

公开(公告)号：EP4446301A2

公开(公告)日：2024-10-16

申请号：EP24184079.2

申请日：2016-01-13

申请人： British Columbia Cancer Agency Branch ,  The University of British Columbia University-Industry Liaison Office

发明人： SADAR, Marianne Dorothy ,  MAWJI, Nasrin R. ,  BANUELOS, Carmen Adriana ,  ANDERSEN, Raymond John ,  FERNANDEZ, Javier Garcia ,  JIAN, Kunzhong

IPC分类号： C07B59/00

摘要： Compounds having a structure of Formula I:

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 , R 2 , R 3 , R 11a , R 11b , R 11c , R 11d , X, n 1 , n 2 , and n 3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

公开(公告)号：EP3988541A1

公开(公告)日：2022-04-27

申请号：EP21212648.6

申请日：2016-01-13

申请人： British Columbia Cancer Agency Branch ,  The University of British Columbia University-Industry Liaison Office

发明人： SADAR, Marianne Dorothy ,  MAWJI, Nasrin R. ,  BANUELOS, Carmen Adriana ,  ANDERSEN, Raymond John ,  FERNANDEZ, Javier Garcia ,  JIAN, Kunzhong

IPC分类号： C07D233/60 ,  C07D249/04 ,  C07D265/30 ,  C07D295/088 ,  A61K31/4164 ,  A61K31/4192 ,  A61K31/495 ,  A61K51/04 ,  A61P35/00 ,  A61K31/5375 ,  C07B59/00

摘要： Compounds having a structure of Formula I:

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 , R 2 , R 3 , R 11a , R 11b , R 11c , R 11d , X, n 1 , n 2 , and n 3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

公开(公告)号：EP3956346A1

公开(公告)日：2022-02-23

申请号：EP20791838.4

申请日：2020-04-17

申请人： Provincial Health Services Authority ,  The University of British Columbia University-Industry Liaison Office

发明人： BÉNARD, Francois ,  LIN, Kuo-Shyan ,  ROUSSEAU, Etienne ,  ZHANG, Zhengxing ,  KWON, Daniel ,  LAU, Joseph ,  MUNOZ, Carlos Uribe ,  LOZADA, Jerome ,  PERRIN, David

IPC分类号： C07K7/56 ,  A61K51/04 ,  A61P35/00 ,  C07K7/06

公开(公告)号：EP3517625A1

公开(公告)日：2019-07-31

申请号：EP19152969.2

申请日：2015-05-22

申请人： The University of British Columbia University-Industry Liaison Office

发明人： HANSEN, Carl Lars Genghis ,  MEWIS, Georgia Elizabeth ,  HEYRIES, Kevin Albert ,  VANINSBERGHE, Michael Andrew ,  DA COSTA, Daniel Jay ,  RICICOVA, Marketa

IPC分类号： C12Q1/68 ,  C07K14/705 ,  C40B20/00 ,  G01N33/68 ,  G16B40/00 ,  C12N5/078

摘要： Provided herein are high-throughput sequencing methods to study the diversity and functionality of lymphocyte receptor chains and pairing of the same. Specifically, the methods provided herein are used to identify with confidence one or more lymphocyte receptor chain pairs in a sample, for example one or more functional chain pairs.