公开(公告)号：EP3714943A1

公开(公告)日：2020-09-30

申请号：EP19305448.3

申请日：2019-04-05

申请人： Université De Bretagne Occidentale - UBO ,  Centre Hospitalier Régional et Universitaire de Brest ,  Inserm

发明人： MIGNEN, Olivier ,  RENAUDINEAU, Yves ,  DEBANT, Marjolaine ,  HEMON, Patrice

IPC分类号： A61P35/00 ,  A61P37/00 ,  C07K16/28

摘要： The present invention relates to a compound that specifically binds to the region between amino acid residues 58 and 201 of the human STIM1 amino acid sequence SEQ ID NO: 1.
The present invention also relates to a composition comprising a therapeutically effective amount of the compound, a host cell that produces an isolated antibody, an isolated nucleic acid sequence encoding the isolated antibody and an expression vector comprising the nucleic acid.
The present invention additionally relates to a method of producing the isolated antibody, to the isolated antibody for its use as a drug, especially for its use in treating a condition or a disorder in which the STIM1 protein localized to the plasma membrane of the cells is overexpressed, and to an isolated protein fragment consisting of the region between amino acid residues 58 and 201 for developing modulators of the STIM1 amino acid sequence SEQ ID NO: 1.

公开(公告)号：EP3714942A1

公开(公告)日：2020-09-30

申请号：EP19305447.5

申请日：2019-04-05

申请人： Université De Bretagne Occidentale - UBO ,  Centre Hospitalier Régional et Universitaire de Brest ,  Inserm

发明人： MIGNEN, Olivier ,  RENAUDINEAU, Yves ,  DEBANT, Marjolaine ,  HEMON, Patrice

IPC分类号： A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  A61K39/395

摘要： The present invention relates to a compound that specifically binds to the region between amino acid residues 58 and 201, preferably 97 and 127 of the human STIM1 amino acid sequence SEQ ID NO: 1.
The present invention also relates to a composition comprising a therapeutically effective amount of the compound, a host cell that produces an isolated antibody, an isolated nucleic acid sequence encoding the isolated antibody and an expression vector comprising the nucleic acid.
The present invention additionally relates to a method of producing the isolated antibody, to the isolated antibody for its use as a drug, especially for its use in treating a condition or a disorder in which the STIM1 protein localized to the plasma membrane of the cells is overexpressed, and to an isolated protein fragment consisting of the region between amino acid residues 97 and 127 for developing modulators of the STIM1 amino acid sequence SEQ ID NO: 1.