公开(公告)号：EP3068756A1

公开(公告)日：2016-09-21

申请号：EP14806041.1

申请日：2014-11-07

申请人： Pivert ,  Centre National de la Recherche Scientifique (CNRS) ,  University of Artois

发明人： HAPIOT, Frédéric ,  MONFLIER, Eric ,  VANBESIEN, Théodore

IPC分类号： C07C67/347 ,  C11C3/12

CPC分类号： C11C3/00 ,  C07C67/313 ,  C07C67/347 ,  C11C3/126 ,  C07C69/716

摘要： The invention relates to a method for the hydroformylation of triglycerides by homogeneous catalysis in the presence of at least one substituted cyclodextrin, said method comprising a step a) of combining, under agitation, at least one catalyst, water, at least one unsaturated triglyceride and said substituted cyclodextrin, in the presence of gaseous hydrogen and carbon monoxide, said step being carried out in reactive conditions allowing the formation of an emulsion during the agitation and a decanting of the products once the agitation has stopped.

摘要翻译： 本发明涉及在存在至少一种取代的环糊精的情况下通过均相催化加氢甲酰化甘油三酸酯的方法，所述方法包括步骤a）在搅拌下将至少一种催化剂，服务员，至少一种不饱和甘油三酯和 所述取代的环糊精在气态氢气和一氧化碳的存在下，所述步骤在反应条件下进行，允许在搅拌期间形成乳剂，并且一旦搅拌停止，则产物倾析。

公开(公告)号：EP2978840B1

公开(公告)日：2020-09-30

申请号：EP14722738.3

申请日：2014-03-26

申请人： BIOCANT - CENTRO DE INOVAÇÃO EM BIOTECNOLOGIA ,  University of Artois

发明人： DA SILVA FERREIRA, Lino ,  SEVIN, Emmanuel, Bernard ,  CECCHELLI, Roméo Paul ,  ADAY, Sezin

IPC分类号： C12N5/071

公开(公告)号：EP2978840A1

公开(公告)日：2016-02-03

申请号：EP14722738.3

申请日：2014-03-26

申请人： Biocant Park - Centro De Inovação Em Biotecnologia ,  University of Artois

发明人： DA SILVA FERREIRA, Lino ,  SEVIN, Emmanuel, Bernard ,  CECCHELLI, Roméo Paul ,  ADAY, Sezin

IPC分类号： C12N5/071

摘要： The present disclosure relates to a method for obtaining human brain-like endothelial cells by contacting a population of cells isolated from stem cells with a differentiation medium to obtain endothelial cells and co-culturing said endothelial cells with pericytes, with cells of the neurovascular unit or with a pericytes conditioned medium, to obtain brain-like endothelial cells. The present disclosure also relates to the use of the brain-like endothelial cells as an in vitro model of human blood-brain barrier and a kit for measuring blood-brain barrier permeability of a substance, comprising in vitro human endothelial cells.

摘要翻译： 本公开内容涉及一种通过将从干细胞分离的细胞群与分化培养基接触以获得内皮细胞并与周细胞共培养所述内皮细胞，与神经血管单位的细胞或者 用周细胞条件培养基，以获得脑样内皮细胞。 本公开还涉及脑样内皮细胞作为人血脑屏障的体外模型和用于测量包含体外人内皮细胞的物质的血脑屏障通透性的试剂盒的用途。