-
1.发明公开COMPOUNDS AND METHODS FOR THE INHIBITION OF PROTEIN-PROTEIN INTERACTIONS 审中-公开化合物和方法抑制蛋白质 - 蛋白质相互作用的
公开(公告)号：EP1038021A4
公开(公告)日：2005-02-16
申请号：EP98961858
申请日：1998-12-02
申请人： WAY JEFFREY C
发明人： WAY JEFFREY C
IPC分类号： G01N33/50 , A61K45/00 , C07B61/00 , C07C57/58 , C07C205/37 , C40B30/04 , C40B40/04 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01N33/543
CPC分类号： G01N33/6845 , C40B30/04 , C40B40/00 , G01N33/68
-
2.发明公开COMPOUNDS AND METHODS FOR THE INHIBITION OF PROTEIN-PROTEIN INTERACTIONS 审中-公开化合物和方法抑制蛋白质 - 蛋白质相互作用的
公开(公告)号：EP1038021A1
公开(公告)日：2000-09-27
申请号：EP98961858.2
申请日：1998-12-02
申请人： Way, Jeffrey C.
发明人： Way, Jeffrey C.
IPC分类号： C12Q1/00 , C12Q1/70 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/543
CPC分类号： G01N33/6845 , C40B30/04 , C40B40/00 , G01N33/68
摘要： Compounds having molecular weights of less than 1500 daltons that non-covalently interact with target proteins and covalently bond to target proteins at amino acid side chains that are not part of enzyme active sites, in which covalently bound portions of the compounds sterically block the binding of the target proteins to other proteins, are disclosed. The compounds react with forward reaction rates at least 100 times faster than the forward reaction rates at which the compounds bond to the side chains of the corresponding free amino acids under physiological conditions. Compositions including these compounds and methods for preparing these compounds are also disclosed.
-
搜索结果
2 条记录 (耗时 0.007 秒)
