公开(公告)号：EP4408483A1

公开(公告)日：2024-08-07

申请号：EP22877397.4

申请日：2022-09-30

申请人： Board of Regents, The University of Texas System ,  University of Pennsylvania ,  Hu, Haitao ,  Weissman, Drew

发明人： HU, Haitao ,  WEISSMAN, Drew

IPC分类号： A61K48/00 ,  A61K9/127 ,  A61K38/00 ,  C07H21/04 ,  A61K39/00

CPC分类号： A61K9/5123 ,  A61K9/0019 ,  C07K14/005 ,  C12N2770/2003420130101 ,  C12N15/88 ,  C12N2770/2002220130101 ,  A61K39/12 ,  A61P31/14 ,  A61K2039/5320130101 ,  A61K2039/5555520130101 ,  A61K2039/57520130101

公开(公告)号：EP4304567A1

公开(公告)日：2024-01-17

申请号：EP22768089.9

申请日：2022-03-11

申请人： The Trustees of the University of Pennsylvania ,  Weissman, Drew

发明人： CONTRERAS, Oscar, Marcos ,  GLASSMAN, Patrick ,  NONG, Jia ,  BRENNER, Jacob ,  MUZYKANTOV, Vladimir ,  WEISSMAN, Drew

IPC分类号： A61K9/51 ,  A61K31/03 ,  A61K31/122 ,  A61K31/573 ,  A61K39/00 ,  A61P37/04

公开(公告)号：EP4415752A2

公开(公告)日：2024-08-21

申请号：EP22881744.1

申请日：2022-10-12

申请人： Duke University ,  The Trustees of the University of Pennsylvania ,  Korber, Bette, T. ,  Wagh, Kshitij, G. ,  Shaw, George, M. ,  Weissman, Drew ,  Alameh, Mohamad-Gabriel

发明人： HAYNES, Barton, F. ,  SAUNDERS, Kevin, O. ,  HAHN, Beatrice ,  DING, Wenge ,  RUSSELL, Ronnie, M. ,  KORBER, Bette, T. ,  WAGH, Kshitij, G. ,  SHAW, George, M. ,  WEISSMAN, Drew ,  ALAMEH, Mohamad-Gabriel

IPC分类号： A61K39/21 ,  A61P31/18 ,  C07K14/16 ,  C12N15/49 ,  A61K9/127 ,  A61K39/295 ,  C12N15/85

CPC分类号： A61K39/12 ,  C12N2740/1613420130101 ,  A61K2039/57520130101 ,  A61K2039/5320130101 ,  C07K14/005 ,  C12N2740/1612220130101

公开(公告)号：EP2510099A2

公开(公告)日：2012-10-17

申请号：EP10836557.8

申请日：2010-12-07

申请人： Kariko, Katalin ,  Weissman, Drew ,  Dahl, Gary ,  Person, Anthony ,  Meis, Judith ,  JENDRISAK, Jerome J.

发明人： Kariko, Katalin ,  Weissman, Drew ,  Dahl, Gary ,  Person, Anthony ,  Meis, Judith ,  JENDRISAK, Jerome J.

IPC分类号： C12N15/113 ,  C12N5/071 ,  C12N5/02

CPC分类号： C12N5/0696 ,  A61K38/1709 ,  A61K38/1816 ,  A61K38/44 ,  A61K38/465 ,  A61K38/50 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/47 ,  C07K14/4712 ,  C07K14/505 ,  C12N9/0075 ,  C12N9/22 ,  C12N9/78 ,  C12N15/117 ,  C12N15/85 ,  C12N15/87 ,  C12N2310/17 ,  C12N2310/335 ,  C12N2320/30 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/02 ,  C12Y114/13039 ,  C12Y301/04012 ,  C12Y305/04004

摘要： The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs.