公开(公告)号：EP0643044A1

公开(公告)日：1995-03-15

申请号：EP94401996.7

申请日：1994-09-08

申请人： MITSUBISHI MATERIALS CORPORATION ,  YOSHIDA PHARMACEUTICAL CO., LTD.

发明人： Nishihara, Akira, Mitsubishi Materiaru, K.K. ,  Nakamura, Akihiro, Mitsubishi Materiaru, K.K. ,  Honda, Tsunetoshi, Mitsubishi Materiaru, K.K. ,  Harada, Michio ,  Takizawa, Maki

IPC分类号： C07C279/26 ,  A61K31/155

CPC分类号： C07C279/265

摘要： A novel bis-biguanide compound suitable for use as a disinfectant has the following formula:

   where n is an integer from 2 to 10 inclusive. A pharmaceutically acceptable salt, particularly gluconate salt of the compound is also useful as a disinfectant. The bis-biguanide compound has germicidal activities comparable to those of widely used chlorhexidine with respect to width of antibacterial spectrum and is superior to chlorhexidine in immediate effectiveness. It exhibits excellent germicidal activities against Pyocyaneus bacilli, on which chlorhexidine has poor effect.

摘要翻译： 适用作消毒剂的新型双双胍化合物具有下式：其中n为2-10的整数。 化合物的药学上可接受的盐，特别是葡萄糖酸盐也可用作消毒剂。 双胍类化合物具有与广泛使用的氯己定相比具有抗菌谱宽度的杀菌活性，并且立即有效地优于氯己定。 它对抗细菌具有优良的杀菌活性，其中氯己定具有差的作用。

公开(公告)号：EP0643044B1

公开(公告)日：1997-05-07

申请号：EP94401996.7

申请日：1994-09-08

申请人： MITSUBISHI MATERIALS CORPORATION ,  YOSHIDA PHARMACEUTICAL CO., LTD.

发明人： Nishihara, Akira, Mitsubishi Materiaru, K.K. ,  Nakamura, Akihiro, Mitsubishi Materiaru, K.K. ,  Honda, Tsunetoshi, Mitsubishi Materiaru, K.K. ,  Harada, Michio ,  Takizawa, Maki

IPC分类号： C07C279/26 ,  A61K31/155

CPC分类号： C07C279/265