摘要:
A method of producing an N-alkoxycarbonylpiperidine derivative, comprising reacting an N-aralkylpiperidine derivative represented by the following general formula (1): with a mesyl halide in the presence of a base, thereby obtaining a mesylated product and reacting the mesylated product with a dicarbonate represented by the following general formula (3): wherein R 4 represents an alkyl group, in the presence of hydrogen and a catalyst containing palladium, thereby obtaining an N-alkoxycarbonylpiperidine derivative represented by the following general formula (4): wherein R 4 represents an alkyl group and Ms represents a mesyl group.
摘要:
A process for producing cis-whiskey-lactone represented by formula (A), which is one of the flavoring components of whiskey or wine, selectively and readily, which comprises hydrolyzing the lactone part of trans-whiskey-lactone with potassium hydroxide, adding an alkyl group to the product by the reaction with isopropyl bromide to form isopropyl (3S, 4S)-4-hydroxy-3-methyloctanoate, reacting the formed ester with diethyl azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylic ester to form isopropyl (3S, 4S)-4-(3', 5'-dinitrobenzoyloxy)-3-methyloctanoate, and hydrolying the formed ester with a 2 % aqueous sodium hydroxide solution.
摘要:
A process for producing cis-whiskey-lactone represented by formula (A), which is one of the flavoring components of whiskey or wine, selectively and readily, which comprises hydrolyzing the lactone part of trans-whiskey-lactone with potassium hydroxide, adding an alkyl group to the product by the reaction with isopropyl bromide to form isopropyl (3S, 4S)-4-hydroxy-3-methyloctanoate, reacting the formed ester with diethyl azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylic ester to form isopropyl (3S, 4S)-4-(3', 5'-dinitrobenzoyloxy)-3-methyloctanoate, and hydrolying the formed ester with a 2 % aqueous sodium hydroxide solution.
摘要:
The present invention relates to a process for the preparation of 2′-deoxy-β-adenosine industrially and easily in high yield and with high selectivity of the β-anomer without the use of expensive raw materials or hazardous materials, by reacting a derivative of 1- -halogeno-2-deoxyribose with a derivative of adenine in the presence of a nitrogen base in 1,2,4-trichlorobenzene as a solvent to obtain 3′,5′-disubstituted-2′-deoxy-β-adenosine and subsequently eliminating the protecting groups thereof.
摘要:
A 1,2,2-trimethyl-1-phenylpolydisilane is prepared by condensating 1,2-dichloro-1,2,2-trimethyl-1-phenyl- disilane in the presence of an alkali metal or alkali earth metal, in an aprotic solvent. This polymer is a viscous liquid which has a weight average molecular weight in the range of from 5,000 to 500,000 and a narrow molecular weight distribution, and has various uses as electroconductors, photoresist and optical information recording materials.
摘要:
A novel acid addition salt of 3-aminoquinuclidine, which is an industrially useful compound as an intermediate of medicines and does not exhibit deliquescence, is provided. s In particular, an acid addition salt of 3-aminoquinuclidine selected from the group consisting of racemic 3-aminoquinuclidine, (R)-3-aminoquinuclidine, and (S)-3-aminoquinuclidine, and acid selected from the group consisting of phosphoric acid, sulfuric acid, fumaric acid, terephthalic acid, oxalic acid, p-toluenesulfonic acid, (±)-10-camphorsulfonic acid, and (-)-10-camphorsulfonic acid, is provided.