公开(公告)号：EP0533936A4

公开(公告)日：1993-05-19

申请号：EP92901905

申请日：1991-12-27

申请人： JAPAN TOBACCO INC ,  YUKI GOSEI YAKUHIN KOGYO KK

发明人： EBATA TAKASHI ,  MATSUMOTO KATSUYA ,  KOSEKI KOSHI ,  KAWAKAMI HIROSHI ,  MATSUSHITA HAJIME ,  YOSHIKOSHI HAJIME ,  OKANIWA MASAKAZU

IPC分类号： C07D307/33 ,  C07D315/00 ,  C07D307/32 ,  A61K7/46

CPC分类号： C07D307/33 ,  C07D315/00

摘要： A process for producing cis-whiskey-lactone represented by formula (A), which is one of the flavoring components of whiskey or wine, selectively and readily, which comprises hydrolyzing the lactone part of trans-whiskey-lactone with potassium hydroxide, adding an alkyl group to the product by the reaction with isopropyl bromide to form isopropyl (3S, 4S)-4-hydroxy-3-methyloctanoate, reacting the formed ester with diethyl azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylic ester to form isopropyl (3S, 4S)-4-(3', 5'-dinitrobenzoyloxy)-3-methyloctanoate, and hydrolying the formed ester with a 2 % aqueous sodium hydroxide solution.

公开(公告)号：EP1801102A4

公开(公告)日：2009-07-15

申请号：EP05783619

申请日：2005-09-16

申请人： YUKI GOSEI YAKUHIN KOGYO KK

发明人： SASAKI MIE ,  MATSUMOTO SEIICHIRO

IPC分类号： C07D213/64 ,  C12P17/12 ,  C12R1/01

CPC分类号： C12R1/01 ,  C07D213/64 ,  C07D213/78 ,  C07D213/803 ,  C12N1/20 ,  C12P17/12

摘要： A process for producing 2-hydroxy-4-substituted pyridines microbiologically; novel microbes; and novel compounds. Specifically, a process for the production of 2-hydroxy-4-substituted pyridines by making a microbe or a product of treatment thereof act on a 4-substituted pyridine represented by the general formula (1): (1) (wherein R is methyl, carboxy, carbamoyl, hydroxyiminomethyl, or cyano); Delftia sp. YGK-A649 (FERM BP-10389), Delftia sp. YGK-C217 (FERM BP-10388) and Acidovorax sp. YGK-A854 (FERM BP-10387) which are novel microbes; and 2-hydroxy-4-pyridine aldoximes which are novel compounds.