公开(公告)号：EP1673092A1

公开(公告)日：2006-06-28

申请号：EP04790649.0

申请日：2004-10-18

申请人： 4 AZA Bioscience nv

发明人： WAER, Mark, Jozef, Albert ,  HERDEWIJN, Piet, André, Maurits, Maria ,  DE JONGHE, Steven, Cesar, Alfons ,  MARCHAND, Arnaud, Didier, Marie ,  GAO, Ling-Jie

IPC分类号： A61K31/519 ,  A61K31/551 ,  C07D475/08 ,  A61P37/00 ,  A61P37/06 ,  A61P9/00 ,  A61P25/00 ,  A61P37/08 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07D475/10 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  C07D475/04 ,  C07D475/08 ,  A61K2300/00

摘要： This invention relates to a group of substituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro-derivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system, TNF-α related disorders, viral diseases and cell proliferative disorders.

公开(公告)号：EP1663244A2

公开(公告)日：2006-06-07

申请号：EP04765120.3

申请日：2004-09-13

申请人： 4 AZA Bioscience nv

发明人： WAER, Mark, Jozef, Albert ,  HERDEWIJN, Piet, André, Maurits, Maria ,  DE JONGHE, Steven, Cesar, Alfons ,  MARCHAND, Arnaud, Didier, Marie ,  YUAN, Lin ,  EL HASSANE, Sefrioui

IPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61P29/00 ,  A61P31/00 ,  A61P39/00 ,  A61P3/00 ,  A61P25/28 ,  A61P35/02 ,  A61P1/16

CPC分类号： C07D475/10 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  C07D475/04 ,  C07D475/08 ,  A61K2300/00

摘要： This invention relates to the use of a group of pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydroderivatives and enantiomers, for the manufacture of a medicament for the prevention or treatment of TNF-α related disorders.

公开(公告)号：EP1658081A2

公开(公告)日：2006-05-24

申请号：EP04761485.4

申请日：2004-08-27

申请人： 4 AZA Bioscience nv

发明人： WAER, Mark, Jozef, Albert ,  HERDEWIJN, Piet, André, Maurits, Maria ,  PFLEIDERER, Wolfgang, Eugen ,  MARCHAND, Arnaud, Didier, Marie ,  DE JONGHE, Steven, Cesar, Alfons

IPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D475/04 ,  C07D475/08 ,  C07D475/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P9/00 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D475/10 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  C07D475/04 ,  C07D475/08 ,  A61K2300/00

摘要： This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro- derivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.