公开(公告)号：EP2997982A1

公开(公告)日：2016-03-23

申请号：EP14797907.4

申请日：2014-05-07

申请人： A School Corporation Kansai University ,  Kawasumi Laboratories, Inc.

发明人： OHYA, Yuichi ,  YOSHIDA, Yasuyuki ,  TAKAHASHI, Akihiro ,  MUKAI, Tomokazu ,  KANEHIRA, Koji

IPC分类号： A61L15/64 ,  A61K31/765 ,  A61K31/77 ,  A61P41/00 ,  C08G63/664 ,  C08L67/04

CPC分类号： C08L67/04 ,  A61K31/765 ,  A61K31/77 ,  A61L31/041 ,  C08G63/664 ,  C08L71/02

摘要： The present invention relates to an adhesion-preventing material comprising the following (1) and (2): (1) an A-B-A type or B-A-B type triblock copolymer that has an A segment containing poly(ε-caprolactone-co-glycolic acid) and a B segment containing polyethylene glycol; and (2) polyethylene glycol and/or methoxy-polyethylene glycol. The present invention provides an adhesion-preventing material that undergoes a sol-gel transition in response to temperature, that can be prepared before use more easily than before, that can be easily applied to invasion sites having a complicated shape or structure, that can exhibit an adhesion-preventing effect stably for a desired period of time, and that has excellent handling properties in laparoscopic surgery.

摘要翻译： 本发明涉及包含以下（1）和（2）的粘合防止材料：（1）具有含有聚（ε-己内酯 - 共 - 乙醇酸）的A链段的ABA型或BAB型三嵌段共聚物和 含有聚乙二醇的B段; 和（2）聚乙二醇和/或甲氧基聚乙二醇。 本发明提供了一种防粘连材料，其能够响应于可以在使用前比以前更容易地制备的温度进行溶胶 - 凝胶转变，其可以容易地应用于具有复杂形状或结构的侵入位点，其可以显示出 在期望的时间内稳定地具有防粘连作用，并且在腹腔镜手术中具有优异的处理性能。