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8 条记录 (耗时 0.018 秒)

    NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION
    1.
    发明公开
    NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION 审中-公开
    多巴胺神经传递的新调节剂

    公开(公告)号：EP1240143A1

    公开(公告)日：2002-09-18

    申请号：EP00989163.1

    申请日：2000-12-22

    申请人： A. Carlsson Research AB

    发明人： ANDERSSON, Bengt ,  SONESSON, Clas ,  WATERS, Susanna ,  WATERS, Nicholas ,  TEDROFF, Joakim

    IPC分类号： C07D211/18 ,  C07D241/04 ,  C07D295/096 ,  C07D295/073 ,  C07D295/155 ,  A61K31/496 ,  A61K31/451 ,  A61P25/00

    CPC分类号： C07D295/073 ,  C07D211/18 ,  C07D241/04 ,  C07D295/096

    摘要： New substituted 4-(phenyl N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1) wherein X is N, CH, or C, however X may only be C when the compound comprises a double bind at the dotted line; R1 is CF3, OSO2CF3, OSO2CH3, SOR7, SO2R7, COR7, CN, OR3, NO2, CONHR3, 3-thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl, Br, or I; R2 is F, Cl, Br, I, CN, CF3, CH3, OCH3, OH, and NH2; R3 and R4 are independently H or a C1-C4 alkyl; R5 is a C1-C4 alkyl, an allyl, CH2SCH3, CH2CH2OCH3, CH2CH2CH2F, CH2CF3, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or -(CH2)-R6; R6 is a C3-C6 cycloalkyl, 2-tetrahydrofurane, or 3-tetrahydrofurane; R7 is a C1-C3 alkyl, CF3, or N(R4)2, and pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed.

    NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION
    2.
    发明公开
    NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION 有权
    多巴胺神经递质的新调节剂

    公开(公告)号：EP1240141A1

    公开(公告)日：2002-09-18

    申请号：EP00989161.5

    申请日：2000-12-22

    申请人： A. Carlsson Research AB

    发明人： ANDERSSON, Bengt DI ,  SONESSON, Clas ,  WATERS, Susanna ,  WATERS, Nicholas ,  TEDROFF, Joakim

    IPC分类号： C07D211/18 ,  C07D241/04 ,  A61K31/496 ,  A61K31/451 ,  A61P25/00

    CPC分类号： C07D295/073 ,  C07D211/18 ,  C07D211/20 ,  C07D211/22 ,  C07D211/24 ,  C07D211/32 ,  C07D211/34 ,  C07D211/70 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D405/06

    摘要： New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1) wherein X is N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; R1 is OSO2CF3, OSO2CH3, SOR5, SO2R5, COR5, CN, NO2, CONHR5, CF3, 3-thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl, Br, or I; R2 is a C1-C4 alkyl, an allyl, CH2SCH3, CH2CH2OCH3, CH2CH2CH2F, CH2CF3, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or -(CH2)-R6; R3 and R4 are independently selected from the group consisting of H and C1-C4 alkyls, however both R3 and R4 cannot be H at the same time; R5 is C1-C3 alkyls, CF3, or N(R2)2; R6 is a C3-C6 cycloalkyl, 2-tetrahydrofurane, or 3-tetra-hydrofurane, as well as pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used are disclosed.

    摘要翻译： 其中X是N，CH或C的新的3-取代的4-（苯基-N-烷基） - 哌嗪和式（1）的4​​-（苯基-N-烷基） - 哌啶化合物，然而X可以仅为C 该化合物在虚线处包含双键; R1是OSO2CF3，OSO2CH3，SOR5，SO2R5，COR5，CN，NO2，CONHR5，CF3,3-噻吩，2-噻吩，3-呋喃，2-呋喃，F，Cl，Br或I; R2是C1-C4烷基，烯丙基，CH2SCH3，CH2CH2OCH3，CH2CH2CH2F，CH2CF3,3,3,3-三氟丙基，4,4,4-三氟丁基或 - （CH2）-R6; R3和R4独立地选自H和C1-C4烷基，然而R3和R4不能同时为H; R5是C1-C3烷基，CF3或N（R2）2; R 6是C 3 -C 6环烷基，2-四氢呋喃或3-四氢呋喃及其药学上可接受的盐。 还公开了包含上述化合物和其中使用上述化合物的方法的药物组合物。

    NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION
    4.
    发明公开
    NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION 有权
    多巴胺神经递质的新调节剂

    公开(公告)号：EP1240142A1

    公开(公告)日：2002-09-18

    申请号：EP00989162.3

    申请日：2000-12-22

    申请人： A. Carlsson Research AB

    发明人： ANDERSSON, Bengt ,  SONESSON, Clas ,  WATERS, Susanna ,  WATERS, Nicholas ,  TEDROFF, Joakim

    IPC分类号： C07D211/18 ,  C07D295/096 ,  C07D295/155 ,  C07D295/073 ,  A61K31/496 ,  A61K31/451 ,  A61P25/00

    CPC分类号： C07D295/073 ,  C07D211/18 ,  C07D211/20 ,  C07D211/22 ,  C07D211/24 ,  C07D211/32 ,  C07D211/34 ,  C07D211/70 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D405/06

    摘要： New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1), wherein X N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; R1 is OSO2CF3, OSO2CH3, SOR3, SO2R3, COR3, NO2, or CONHR3 and when X is CH or C R1 may also be CF3, CN, F, C1, Br, or I; R2 is a C1-C4 alkyl, an allyl, CH2SCH3, CH2CH2OCH3, CH2CH2CH2F, CH2CF3, 3,3,3-trifluoropropyl, 4,4,4- trifluorobutyl, or - (CH2) - R4; R3 is a C1-C3 alkyl, CF3, or N(R2)2; R4 is a C3-C6 cycloalkyl, 2-tetrahydrofurane or 3-tetra-hydrofurane, as well as pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed.

    摘要翻译： 式（1）的新的3-取代的4-（苯基-N-烷基） - 哌嗪和4-（苯基-N-烷基） - 哌啶化合物，其中XN，CH或C，然而X可以仅为 化合物在虚线处包含双键; R1是OSO2CF3，OSO2CH3，SOR3，SO2R3，COR3，NO2或CONHR3，并且当X是CH或C时，R1也可以是CF3，CN，F，C1，Br或I; R2为C1-C4烷基，烯丙基，CH2SCH3，CH2CH2OCH3，CH2CH2CH2F，CH2CF3,3,3,3-三氟丙基，4,4,4-三氟丁基或 - （CH2）-R4; R3是C1-C3烷基，CF3或N（R2）2; R 4是C 3 -C 6环烷基，2-四氢呋喃或3-四氢呋喃及其药学上可接受的盐。 还公开了包含上述化合物和其中上述化合物用于治疗中枢神经系统病症的方法的药物组合物。