-
1.发明公开METHOD OF PREPARING ENANTIOMERICALLY-PURE 3-METHYL-5-(1-ALKYL-2(S)-PYRROLIDINYL)ISOXAZOLES 失效用于制备对映体纯的3-甲基-5-（1-烷基-2-（S） - 吡咯烷基）的方法，异恶唑
公开(公告)号：EP0717741A1
公开(公告)日：1996-06-26
申请号：EP94931741.0
申请日：1994-08-30
申请人： ABBOTT LABORATORIES
发明人： LIN, Nan-Horng , HE, Yun , ELLIOTT, Richard, L. , CHORGHADE, Mukund, S. , WITTENBERGER, Steven, J. , BUNNELLE, William, H. , NARAYANAN, Bikshandar, A. , SINGAM, Pulla R., Apartment 302 , ESCH, Thomas, K., J. , BEER, Dieter, O. , WITZIG, Christian, C. , HERZIG, Thomas, C. , RAO, Alla, V. Rama, Residence of Director
IPC分类号： C07D413
CPC分类号： C07D413/04
摘要： A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
-
2.发明授权METHOD OF PREPARING ENANTIOMERICALLY-PURE 3-METHYL-5-(1-ALKYL-2(S)-PYRROLIDINYL)ISOXAZOLES 失效用于制备对映体纯的3-甲基-5-（1-烷基-2-（S） - 吡咯烷基）的方法，异恶唑
公开(公告)号：EP0717741B1
公开(公告)日：2001-05-30
申请号：EP94931741.6
申请日：1994-08-30
申请人： ABBOTT LABORATORIES
发明人： LIN, Nan-Horng , HE, Yun , ELLIOTT, Richard, L. , CHORGHADE, Mukund, S. , WITTENBERGER, Steven, J. , BUNNELLE, William, H. , NARAYANAN, Bikshandar, A. , SINGAM, Pulla R., Apartment 1116 , ESCH, Thomas, K., J. , BEER, Dieter, O. , WITZIG, Christian, C. , HERZIG, Thomas, C. , RAO, Alla, V. Rama, Residence of Director
IPC分类号： C07D413/04 , C07D207/09
CPC分类号： C07D413/04
摘要： A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
-
搜索结果
2 条记录 (耗时 0.009 秒)
