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公开(公告)号：EP2539439B1
公开(公告)日：2018-10-17
申请号：EP11747958.4
申请日：2011-02-23
申请人： ABT Holding Company
CPC分类号： A61K35/545 , G01N33/5008
摘要： The invention provides methods for treating pathological conditions that can be improved by providing angiogenesis. The invention is generally directed to provide angiogenesis by administering cells that express and/or secrete one or more pro-angiogenic factors. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to express and/or secrete one or more pro-angiogenic factors. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired levels of expression and/or secretion of one or more pro-angiogenic factors.
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公开(公告)号：EP2539439A1
公开(公告)日：2013-01-02
申请号：EP11747958.4
申请日：2011-02-23
申请人： ABT Holding Company
CPC分类号： A61K35/545 , G01N33/5008
摘要： The invention provides methods for treating pathological conditions that can be improved by providing angiogenesis. The invention is generally directed to provide angiogenesis by administering cells that express and/or secrete one or more pro-angiogenic factors. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to express and/or secrete one or more pro-angiogenic factors. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired levels of expression and/or secretion of one or more pro-angiogenic factors.
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公开(公告)号：EP2456853A1
公开(公告)日：2012-05-30
申请号：EP10802840.8
申请日：2010-07-21
申请人： ABT Holding Company
IPC分类号： C12N3/00
摘要： The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in vascular endothelial cells. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to the endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non-embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential.
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