公开(公告)号：EP3940060A1

公开(公告)日：2022-01-19

申请号：EP21175415.5

申请日：2011-02-24

申请人： ABT Holding Company ,  Case Western Reserve University

发明人： TING, Anthony, E. ,  MAYS, Robert, W. ,  HAMILTON, Jason, A. ,  BUSCH, Sarah, A. ,  SILVER, Jerry

IPC分类号： C12N5/074 ,  C12N5/00 ,  A61K35/12 ,  A61P29/00

摘要： The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that modulate macrophage activation. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to modulate macrophage activation. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency to modulate macrophage activation.

公开(公告)号：EP2539436A1

公开(公告)日：2013-01-02

申请号：EP11748062.4

申请日：2011-02-24

申请人： ABT Holding Company ,  Case Western Reserve University

发明人： TING, Anthony, E. ,  MAYS, Robert, W. ,  HAMILTON, Jason, A. ,  BUSCH, Sarah, A. ,  SILVER, Jerry

IPC分类号： C12N5/00

CPC分类号： C12N5/0607 ,  A61K2035/122 ,  A61K2035/124

摘要： The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that modulate macrophage activation. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to modulate macrophage activation. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency to modulate macrophage activation.

摘要翻译： 本发明提供了用于治疗与不期望的炎症成分相关的病理状态的方法。 本发明总体上涉及通过施用调节巨噬细胞活化的细胞来减轻炎症。 本发明还涉及筛选调节细胞调节巨噬细胞活化能力的药物的药物发现方法。 本发明还涉及可用于提供给受试者施用细胞的细胞库，所述库包含具有调节巨噬细胞活化所需效力的细胞。