公开(公告)号：EP3743427A1

公开(公告)日：2020-12-02

申请号：EP19701346.9

申请日：2019-01-22

申请人： AC Immune SA ,  Life Molecular Imaging SA

发明人： ZERNA, Marion ,  BERNDT, Mathias ,  SCHIEFERSTEIN, Hanno ,  CASTILLO MELEAN, Johnny ,  KROTH, Heiko ,  MOLETTE, Jérôme ,  DARMENCY, Vincent ,  GABELLIERI, Emanuele

IPC分类号： C07D471/14 ,  A61K51/04 ,  C07B59/00

公开(公告)号：EP3743115A1

公开(公告)日：2020-12-02

申请号：EP19700951.7

申请日：2019-01-22

申请人： AC Immune SA ,  Life Molecular Imaging SA

发明人： CASTILLO MELEAN, Johnny ,  BETZEL, Thomas ,  BERNDT, Mathias ,  SCHIEFERSTEIN, Hanno ,  KROTH, Heiko ,  MOLETTE, Jérôme ,  DARMENCY, Vincent ,  GABELLIERI, Emanuele

IPC分类号： A61K51/04 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K101/02 ,  C07D471/14

公开(公告)号：EP3487544A1

公开(公告)日：2019-05-29

申请号：EP17752300.8

申请日：2017-07-21

申请人： AC Immune S.A. ,  Life Molecular Imaging SA

发明人： KROTH, Heiko ,  MOLETTE, Jérôme ,  DARMENCY, Vincent ,  SCHIEFERSTEIN, Hanno ,  MÜLLER, Andre ,  SCHMITT-WILLICH, Heribert ,  BERNDT, Mathias ,  ODEN, Felix ,  GABELLIERI, Emanuele

IPC分类号： A61K51/04 ,  C07B59/00

公开(公告)号：EP4370521A1

公开(公告)日：2024-05-22

申请号：EP22747699.1

申请日：2022-07-15

申请人： AC Immune SA

发明人： KROTH, Heiko ,  DARMENCY, Vincent ,  DREYFUS, Nicolas ,  BOUDOU, Cédric

IPC分类号： C07D513/04 ,  A61P25/28 ,  A61K31/437

CPC分类号： C07D513/04 ,  A61P25/28

公开(公告)号：EP4001277A3

公开(公告)日：2022-09-14

申请号：EP21214388.7

申请日：2017-03-10

申请人： AC Immune SA

发明人： MOLETTE, Jérôme ,  GABELLIERI, Emanuele ,  DARMENCY, Vincent

IPC分类号： C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  A61K31/4427 ,  A61K31/4365 ,  A61K31/4439 ,  A61P25/28 ,  A61P25/16 ,  A61P25/00

摘要： The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity, of a group of disorders and abnormalities associated with alpha-synuclein (a-synuclein, A-synuclein, aSynuclein, A-syn, α-syn, aSyn) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease. The instant compounds are particularly useful in determining a predisposition to such a disorder, monitoring residual disorder, or predicting the responsiveness of a patient who is suffering from such a disorder to the treatment with a certain medicament. The present compounds can also be used to treat, alleviate or prevent a disorder or abnormality associated with alpha-synuclein aggregates.

公开(公告)号：EP4001277A2

公开(公告)日：2022-05-25

申请号：EP21214388.7

申请日：2017-03-10

申请人： AC Immune SA

发明人： MOLETTE, Jérôme ,  GABELLIERI, Emanuele ,  DARMENCY, Vincent

IPC分类号： C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  A61K31/4427 ,  A61K31/4365 ,  A61K31/4439 ,  A61P25/28 ,  A61P25/16 ,  A61P25/00

摘要： The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity, of a group of disorders and abnormalities associated with alpha-synuclein (a-synuclein, A-synuclein, aSynuclein, A-syn, α-syn, aSyn) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease. The instant compounds are particularly useful in determining a predisposition to such a disorder, monitoring residual disorder, or predicting the responsiveness of a patient who is suffering from such a disorder to the treatment with a certain medicament. The present compounds can also be used to treat, alleviate or prevent a disorder or abnormality associated with alpha-synuclein aggregates.

公开(公告)号：EP3426653A1

公开(公告)日：2019-01-16

申请号：EP17715405.1

申请日：2017-03-10

申请人： AC Immune SA

发明人： MOLETTE, Jérôme ,  GABELLIERI, Emanuele ,  DARMENCY, Vincent

IPC分类号： C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  A61K31/4427 ,  A61K31/4365 ,  A61K31/4439 ,  A61P25/00