公开(公告)号：EP3152292A1

公开(公告)日：2017-04-12

申请号：EP15728918.2

申请日：2015-06-02

申请人： ACD Pharmaceuticals AS

发明人： KLEPPEN, Hans Petter ,  BÅRDSEN, Eirik ,  MARTÍNEZ, Juan José Jiménez

IPC分类号： C12M1/107 ,  C12M3/00 ,  C12M1/00 ,  C12M1/02 ,  C12M1/21

CPC分类号： C12M21/04 ,  C12M21/08 ,  C12M21/14 ,  C12M23/02 ,  C12M23/06 ,  C12M23/34 ,  C12M27/00 ,  C12M29/08 ,  C12M29/20 ,  C12M41/02

摘要： The present invention relates to the field of fermentation. In particular, the present invention relates to a method and apparatus for production of products by use of living cells or active components derived from such cells using a bioreactor having a built in gas distributor and a specific system/device for handling foam formed in the process. The invention also relates to a bioreactor comprising: a reaction chamber having a fermentation zone and a foam settling zone, wherein the reaction chamber is arranged such that the foam settling zone is spaced from or physically separated from the fermentation zone so as to reduce the effect of activity in the fermentation zone on foam in the settling zone. The separation of the fermentation zone from the activity of the fermentation zone encourages settling of the foam. The invention also provides a method of forming a bioreactor comprising: overlapping two flat, flexible sheets of material; and causing said two sheets to adhere to each other in selected areas so as to define a reaction chamber. This is a particularly cost-effective way to produce a single use, disposable reactor.

摘要翻译： 本发明涉及发酵领域。 特别地，本发明涉及使用具有内置气体分配器的生物反应器和用于处理在该方法中形成的泡沫的特定系统/装置，使用来自这种细胞的活细胞或活性成分来生产产品的方法和装置 。 本发明还涉及一种生物反应器，包括：具有发酵区和泡沫沉降区的反应室，其中反应室被布置成使得泡沫沉降区与发酵区间隔开或与发酵区物理分离，以便降低效果 在沉降区的泡沫发酵区的活性。 发酵区域与发酵区域的活性分离有助于泡沫沉降。 本发明还提供了一种形成生物反应器的方法，包括：重叠两个平的柔性片材; 并使所述两片在所选择的区域中相互粘合从而限定反应室。 这是生产单次使用的一次性反应器的特别具有成本效益的方法。