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1.发明公开COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USES AS IDH1 MUTANTS INHIBITORS FOR TREATING CANCERS 有权化合物，其药物组合物及其作为IDH1突变体抑制剂用于癌症治疗
公开(公告)号：EP2721033A4
公开(公告)日：2014-11-05
申请号：EP12799802
申请日：2012-06-18
发明人： CAO SHELDON , POPOVICI-MULLER JANETA , SALITURO FRANCESCO G , SAUNDERS JEFFREY O , TAN XUEFEI , TRAVINS JEREMY , YAN SHUNQI , YE ZHIXIONG
IPC分类号： C07D491/052 , A61K31/496 , A61P35/00 , C07D217/26 , C07D413/04 , C07D519/00
CPC分类号： C07D491/052 , A61K31/496 , A61K31/519 , A61K31/551 , C07D217/22 , C07D217/26 , C07D401/04 , C07D405/12 , C07D413/04 , C07D471/04 , C07D519/00
摘要： Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.
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公开(公告)号：EP2721019A4
公开(公告)日：2014-11-19
申请号：EP12800001
申请日：2012-06-18
发明人： CAO SHELDON , POPOVICI-MULLER JANETA , SALITURO FRANCESCO G , SAUNDERS JEFFREY O , TRAVINS JEREMY , TAN XUEFEI , YAN SHUNQI , YE ZHIXIONG
IPC分类号： C07D213/85 , A61K31/44 , A61K31/496 , A61P35/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07F9/650952 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/675 , C07D213/85 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07F9/65583
摘要： Provided are compounds with the following structure, formula (I) pharmaceutically acceptable salts thereof, use of those compounds for treating cancer and pharmaceutical compositions comprising those compounds.
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公开(公告)号：EP3119199A4
公开(公告)日：2017-11-15
申请号：EP15764391
申请日：2015-03-20
发明人： CIANCHETTA GIOVANNI , LEMIEUX RENE M , CAO SHELDON , DING YUE , YE ZHIXIONG
CPC分类号： C07D417/08 , C07D237/14 , C07D237/20 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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公开(公告)号：EP2970189A4
公开(公告)日：2016-08-10
申请号：EP14765650
申请日：2014-03-13
发明人： CIANCHETTA GIOVANNI , POPOVICI-MULLER JANETA , ZAHLER ROBERT , CAO SHELDON , WANG XIAOLEI , YE ZHIXIONG
IPC分类号： C07D401/10 , A61K31/18 , A61K31/428 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/4738 , A61K31/495 , A61P7/06 , A61P35/02 , C07D401/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12 , C07F9/09
CPC分类号： C07D401/12 , C07D211/48 , C07D211/52 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , C07F9/65583
摘要： Compounds of general formula I: and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.
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