公开(公告)号：EP2874639A4

公开(公告)日：2016-05-11

申请号：EP13799943

申请日：2013-06-06

申请人： ALKERMES INC

发明人： ALVAREZ JUAN ,  CHAMOUN JEAN ,  LOSEY HEATHER C

IPC分类号： C12N15/62 ,  C07K14/47 ,  C07K14/575 ,  C07K14/715

CPC分类号： C07K14/55 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4713 ,  C07K14/4727 ,  C07K14/50 ,  C07K14/54 ,  C07K14/5412 ,  C07K14/5443 ,  C07K14/545 ,  C07K14/57563 ,  C07K14/70503 ,  C07K14/71 ,  C07K14/7155 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/74 ,  C07K2319/91

摘要： The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.

公开(公告)号：EP2859015A4

公开(公告)日：2015-11-18

申请号：EP13801437

申请日：2013-06-06

申请人： ALKERMES INC

发明人： ALVAREZ JUAN ,  CHAMOUN JEAN

IPC分类号： C07K14/52 ,  C12P21/04 ,  C12P21/06

CPC分类号： C07K14/55 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4713 ,  C07K14/4727 ,  C07K14/50 ,  C07K14/54 ,  C07K14/5412 ,  C07K14/5443 ,  C07K14/545 ,  C07K14/57563 ,  C07K14/70503 ,  C07K14/71 ,  C07K14/7155 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/74 ,  C07K2319/91

摘要： The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.