公开(公告)号：EP0729353A4

公开(公告)日：1998-01-21

申请号：EP95901961

申请日：1994-11-18

申请人： ALKERMES INC

发明人： RAMSTACK J MICHAEL ,  HERBERT PAUL F ,  STROBEL JAN ,  ATKINS THOMAS J ,  HAZRATI AZAR M

IPC分类号： A61K9/50 ,  A61K9/16 ,  A61K31/519 ,  A61K31/568 ,  A61K31/57 ,  A61K47/34 ,  B01J13/02 ,  B01J13/06 ,  B01J13/08

CPC分类号： A61K9/1694 ,  A61K9/1647 ,  B01J13/06 ,  B01J13/08 ,  Y10S977/788 ,  Y10S977/898 ,  Y10S977/90

摘要： A process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent. A first phase, comprising the active agent and the polymer, and a second phase are pumped through a static mixer into a quench liquid to form microparticles containing the active agent. Preferably, a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer.

公开(公告)号：EP2131815A4

公开(公告)日：2012-11-07

申请号：EP08732476

申请日：2008-03-19

申请人： ALKERMES INC

发明人： KUMAR RAJESH ,  TROIANO GREGORY ,  RAMSTACK J MICHAEL ,  HERBERT PAUL ,  FIGA MICHAEL

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K38/22

CPC分类号： A61K9/1647 ,  A61K9/1623 ,  A61K9/1682 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/2278