公开(公告)号：EP1809254A2

公开(公告)日：2007-07-25

申请号：EP05821048.5

申请日：2005-10-28

申请人： ALZA CORPORATION

发明人： WONG, Harry ,  ZHANG, Yuanpeng ,  HUANG, Anthony, Hei-Leung

IPC分类号： A61K9/19 ,  A61K9/127 ,  A61K31/00

CPC分类号： A61K31/337 ,  A61K9/127 ,  A61K9/19 ,  A61K31/00 ,  A61K31/4196 ,  A61K31/4706 ,  A61K31/55 ,  A61K31/573 ,  A61K31/7012 ,  A61K31/7048 ,  A61K31/7072 ,  A61K38/13

摘要： Formulations and methods for preparing a lyophilized composition comprising liposomes comprised of an unsaturated lipid and a hydrophobic drug associated with the liposome, and a cryoprotectant in a solution at a selected concentration. The phase transition temperature of the lipid is greater than the freezing point of the solution at the selected concentration. Preferably the lipid is palmitoyl-oleoylphosphatidylcholine and the cryoprotectant is sucrose.