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1.发明授权STABLE PROTEIN AND NUCLEIC ACID FORMULATIONS USING NON-AQUEOUS, ANHYDROUS, APROTIC, HYDROPHOBIC, NON-POLAR VEHICLES WITH LOW REACTIVITY 失效稳定的蛋白质和核酸制剂使用非水的与水非质子，疏水性，具有低反应不是两极车辆
公开(公告)号：EP0939655B1
公开(公告)日：2002-06-12
申请号：EP97910959.2
申请日：1997-10-15
申请人： ALZA CORPORATION
CPC分类号： A61K9/0019 , A61K9/0014 , A61K9/0024 , A61K9/0026 , A61K9/10 , A61K38/212 , A61K38/38 , A61K38/4826 , A61K38/4846 , A61K47/06 , A61K48/00
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2.发明公开STABLE PROTEIN AND NUCLEIC ACID FORMULATIONS USING NON-AQUEOUS, ANHYDROUS, APROTIC, HYDROPHOBIC, NON-POLAR VEHICLES WITH LOW REACTIVITY 失效稳定蛋白UNT核酸制剂使用非水的与水非质子，疏水性，具有低反应不是两极车辆
公开(公告)号：EP0939655A1
公开(公告)日：1999-09-08
申请号：EP97910959.0
申请日：1997-10-15
申请人： ALZA CORPORATION
CPC分类号： A61K9/0019 , A61K9/0014 , A61K9/0024 , A61K9/0026 , A61K9/10 , A61K38/212 , A61K38/38 , A61K38/4826 , A61K38/4846 , A61K47/06 , A61K48/00
摘要： This invention relates to stable non-aqueous formulations which are suspensions of proteinaceous substances or nucleic acids in non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity. More specifically, the present invention relates to stable protein or nucleic acid formulations wherein the compound remains in stable, dry powder form, yet the formulation is flowable and, therefore amenable to delivery to an animal via injection, transdermal administration, oral delivery or using an implantable device for sustained delivery. These stable formulations may be stored at elevated temperatures (e.g., 37 °C) for long periods of time and are especially useful as flowable formulations which can be shipped and/or stored at high temperatures or in implantable delivery devices for long term delivery (e.g., 1-12 months or longer) of drug.
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