公开(公告)号：EP2269606A3

公开(公告)日：2012-04-25

申请号：EP10013093.9

申请日：2004-10-27

申请人： ALZA Corporation

发明人： Gale, Robert ,  Stein, Thomas ,  Audett, Jay

IPC分类号： A61K9/70 ,  A61K31/4468 ,  A61K31/4535

CPC分类号： A61K45/06 ,  A61K9/7061 ,  A61K9/7084 ,  A61K9/7092 ,  A61K31/4468 ,  A61K31/4535

摘要： A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.

公开(公告)号：EP2269606A2

公开(公告)日：2011-01-05

申请号：EP10013093.9

申请日：2004-10-27

申请人： ALZA Corporation

发明人： Gale, Robert ,  Stein, Thomas ,  Audett, Jay

IPC分类号： A61K31/4468 ,  A61K31/4535 ,  A61K9/70

CPC分类号： A61K45/06 ,  A61K9/7061 ,  A61K9/7084 ,  A61K9/7092 ,  A61K31/4468 ,  A61K31/4535

摘要： A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.

摘要翻译： 具有降低的滥用潜力的透皮镇痛系统，其中所述系统以足以在剂型受到滥用时提供拮抗剂与镇痛剂的滥用限制释放速率比的速率提供拮抗剂的受控释放。

公开(公告)号：EP2308480A3

公开(公告)日：2011-10-05

申请号：EP11152742.0

申请日：2006-09-22

申请人： ALZA Corporation

发明人： Audett, Jay ,  Wen, Jianye ,  Goldman, Eli J ,  Luciano, Allison ,  Foreman, Paul B ,  Silverberg, Eric N ,  Gale, Robert M

IPC分类号： A61K9/70 ,  A61L15/58

CPC分类号： A61K9/7061 ,  A61K9/7038 ,  A61K31/4439 ,  A61K31/465 ,  A61K31/55 ,  A61K31/567 ,  A61K31/57 ,  A61K47/32 ,  C07D401/04

摘要： A polyacrylate formulation suitable for delivery of drug through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.

摘要翻译： 一种聚丙烯酸酯制剂，适用于通过个体体表递送药物。 通过将药物和渗透促进剂以高浓度装载到对于皮肤上的典型粘合剂应用具有不足的粘合性的聚丙烯酸酯辅助粘合剂上，可以制备具有期望的粘合特性和有效治疗性质的制剂。 该辅助粘合剂具有比典型的压敏粘合剂更高的玻璃化转变温度。

公开(公告)号：EP1513507A1

公开(公告)日：2005-03-16

申请号：EP03718492.6

申请日：2003-04-22

申请人： Alza Corporation,c/o Johnson & Johnson

发明人： Gale, Robert ,  Stein, Thomas M. ,  Audett, Jay ,  Stepic, Jane ,  Phipps, Joseph B. ,  Cormier, Michel J. N.

IPC分类号： A61K9/70 ,  A61K31/4468 ,  A61K31/4535

CPC分类号： A61K9/7092 ,  A61K9/7061 ,  A61K31/4468 ,  A61K31/4535 ,  A61K45/06 ,  A61K2300/00

摘要： A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.

公开(公告)号：EP2308480B1

公开(公告)日：2014-08-13

申请号：EP11152742.0

申请日：2006-09-22

申请人： ALZA Corporation

发明人： Audett, Jay ,  Wen, Jianye ,  Goldman, Eli J ,  Luciano, Allison ,  Foreman, Paul B ,  Silverberg, Eric N ,  Gale, Robert M

IPC分类号： A61K9/70 ,  A61L15/58

CPC分类号： A61K9/7061 ,  A61K9/7038 ,  A61K31/4439 ,  A61K31/465 ,  A61K31/55 ,  A61K31/567 ,  A61K31/57 ,  A61K47/32 ,  C07D401/04

公开(公告)号：EP2308480A2

公开(公告)日：2011-04-13

申请号：EP11152742.0

申请日：2006-09-22

申请人： ALZA Corporation

发明人： Audett, Jay ,  Wen, Jianye ,  Goldman, Eli J ,  Luciano, Allison ,  Foreman, Paul B ,  Silverberg, Eric N ,  Gale, Robert M

IPC分类号： A61K9/70 ,  A61L15/58

CPC分类号： A61K9/7061 ,  A61K9/7038 ,  A61K31/4439 ,  A61K31/465 ,  A61K31/55 ,  A61K31/567 ,  A61K31/57 ,  A61K47/32 ,  C07D401/04

摘要： A polyacrylate formulation suitable for delivery of drug through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.

摘要翻译： 适用于通过个体体表输送药物的聚丙烯酸酯制剂。 通过将高浓度的药物和渗透促进剂加载到对皮肤上典型的粘合剂施加具有不良粘合性能的聚丙烯酸酯粘合剂中，可以制备具有所需粘合特性和有效治疗性质的制剂。 该粘合剂比典型的压敏粘合剂具有更高的玻璃化转变温度。