公开(公告)号：EP1112060A1

公开(公告)日：2001-07-04

申请号：EP99944089.4

申请日：1999-09-03

申请人： ALZA Corporation

发明人： DONG, Liang, C. ,  WONG, Patrick, S.- L. ,  ESPINAL, Steven, D.

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

摘要： A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.

公开(公告)号：EP1117383A1

公开(公告)日：2001-07-25

申请号：EP99948122.9

申请日：1999-09-03

申请人： ALZA CORPORATION

发明人： DONG, Liang, C. ,  WONG, Patrick, S.-L. ,  FERRARI, Vincent, J. ,  ESPINAL, Steven, D.

IPC分类号： A61K9/20 ,  A61K9/48

CPC分类号： A61K9/0004

摘要： A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a substained-release period of time up to 24 hours.

公开(公告)号：EP0716595A1

公开(公告)日：1996-06-19

申请号：EP94926618.0

申请日：1994-08-31

申请人： ALZA CORPORATION

发明人： DONG, Liang, C. ,  ESPINAL, Steven, D. ,  WONG, Patrick, S.-L. ,  GUITTARD, George, V. ,  HAMEL, Lawrence, G.

IPC分类号： A61K9 ,  A61K47

CPC分类号： A61K9/0004 ,  A61K9/2013 ,  A61K9/2054

摘要： The present invention is directed to a formulation for the delivery of hydrophobic active agents to a fluid environment of use while avoiding aggregation of the hydrophobic agents in the environment, the formulation comprising a hydrophobic active agent in an amount of 50 wt% (percent by weight) or greater together with polyoxyethylene 40 stearate and a disintegrant. The present invention is also directed to an improvement in a fluid-activated delivery device (10) wherein the delivery device includes a housing (12) defining an internal compartment (14), an active agent formulation (15) in the compartment, exit means (13) in the housing (12) for delivering the active agent formulation (15) from the delivery device, a fluid-activated expandable driving member (16) in the compartment, optionally a partition layer between the active agent formulation (15) and the driving member (16), and optionally a lubricant subcoat (18); wherein the improvement comprises an active agent formulation (15) comprising a hydrophobic active agent in an amount of 50 wt% (percent by weight) or greater together with polyoxyethylene 40 stearate and a disintegrant.

公开(公告)号：EP1117383B1

公开(公告)日：2005-11-23

申请号：EP99948122.9

申请日：1999-09-03

申请人： ALZA CORPORATION

发明人： DONG, Liang, C. ,  WONG, Patrick, S.-L. ,  FERRARI, Vincent, J. ,  ESPINAL, Steven, D.

IPC分类号： A61K9/20 ,  A61K9/48

CPC分类号： A61K9/0004

摘要： A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a substained-release period of time up to 24 hours.

公开(公告)号：EP1239840B1

公开(公告)日：2005-04-06

申请号：EP00984181.8

申请日：2000-12-08

申请人： Alza Corporation

发明人： DONG, Liang, C. ,  ESPINAL, Steven, D. ,  WONG, Patrick, S.-L. ,  MAGRUDER, Paul, R.

IPC分类号： A61K9/22 ,  A61P31/18

CPC分类号： A61K9/0004

摘要： A pharmaceutical composition comprising a liquid antiviral formulation is disclosed. Additionally, a dosage form and a method for administering an antiviral pharmaceutical composition are disclosed.

公开(公告)号：EP1112060B1

公开(公告)日：2005-12-07

申请号：EP99944089.4

申请日：1999-09-03

申请人： ALZA CORPORATION

发明人： DONG, Liang, C. ,  WONG, Patrick, S.- L. ,  ESPINAL, Steven, D.

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

摘要： A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.

公开(公告)号：EP1239840A2

公开(公告)日：2002-09-18

申请号：EP00984181.8

申请日：2000-12-08

申请人： Alza Corporation

发明人： DONG, Liang, C. ,  ESPINAL, Steven, D. ,  WONG, Patrick, S.-L. ,  MAGRUDER, Paul, R.

IPC分类号： A61K9/22 ,  A61P31/18

CPC分类号： A61K9/0004

摘要： A pharmaceutical composition comprising a liquid antiviral formulation is disclosed. Additionally, a dosage form and a method for administering an antiviral pharmaceutical composition are disclosed.

公开(公告)号：EP0716595B1

公开(公告)日：1998-11-25

申请号：EP94926618.3

申请日：1994-08-31

申请人： ALZA CORPORATION

发明人： DONG, Liang, C. ,  ESPINAL, Steven, D. ,  WONG, Patrick, S.-L. ,  GUITTARD, George, V. ,  HAMEL, Lawrence, G.

IPC分类号： A61K9/00 ,  A61K9/20

CPC分类号： A61K9/0004 ,  A61K9/2013 ,  A61K9/2054

摘要： The present invention is directed to a formulation for the delivery of hydrophobic active agents to a fluid environment of use while avoiding aggregation of the hydrophobic agents in the environment, the formulation comprising a hydrophobic active agent in an amount of 50 wt% (percent by weight) or greater together with polyoxyethylene 40 stearate and a disintegrant. The present invention is also directed to an improvement in a fluid-activated delivery device (10) wherein the delivery device includes a housing (12) defining an internal compartment (14), an active agent formulation (15) in the compartment, exit means (13) in the housing (12) for delivering the active agent formulation (15) from the delivery device, a fluid-activated expandable driving member (16) in the compartment, optionally a partition layer between the active agent formulation (15) and the driving member (16), and optionally a lubricant subcoat (18); wherein the improvement comprises an active agent formulation (15) comprising a hydrophobic active agent in an amount of 50 wt% (percent by weight) or greater together with polyoxyethylene 40 stearate and a disintegrant.