公开(公告)号：EP1066081A1

公开(公告)日：2001-01-10

申请号：EP97946628.1

申请日：1997-11-07

申请人： ALZA CORPORATION

发明人： DIONNE, Keith, E. ,  LAUTENBACH, Scott, D. ,  EFTIMIE, Antoaneta, C. ,  LY, Kevin, S.

IPC分类号： A61M31/00

CPC分类号： A61K9/0004

摘要： The present invention relates to an osmotically driven agent delivery system for delivering a beneficial agent. The osmotic delivery system includes an osmotic agent which operates by imbibing fluid from an outside environment, causing the release of a beneficial agent. The osmotic delivery system includes a liquid or gel additive surrounding the osmotic agent for enhancing start-up and lubricating the osmotic agent. The liquid or gel additive is an incompressible lubricating fluid which fills any air gaps between the osmotic agent and the walls of a chamber and substantially reduces start-up delays.

公开(公告)号：EP1011642B1

公开(公告)日：2007-03-28

申请号：EP98937963.1

申请日：1998-07-24

申请人： ALZA CORPORATION

发明人： CHEN, Guohua ,  DIONNE, Keith, E. ,  LAUTENBACH, Scott, D. ,  JORDAN, Scott, D. ,  BERRY, Stephen, A. ,  RODENBERGER, Craig, I. ,  AYER, Rupal

IPC分类号： A61K9/52

CPC分类号： A61K9/0004

摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.

公开(公告)号：EP1551493A1

公开(公告)日：2005-07-13

申请号：EP03762060.6

申请日：2003-06-25

申请人： Alza Corporation

发明人： LAUTENBACH, Scott, D.

IPC分类号： A61M31/00 ,  A61K9/00

CPC分类号： A61K9/48 ,  A61K9/0004 ,  A61M31/002 ,  A61M2005/14513

摘要： An osmotic pump having a minimally compliant, volume efficient piston positioned within a capsule. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length to total diameter ratio of about 1.1:1 and a core diameter to total diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

公开(公告)号：EP1066081B1

公开(公告)日：2003-07-16

申请号：EP97946628.1

申请日：1997-11-07

申请人： ALZA Corporation

发明人： DIONNE, Keith, E. ,  LAUTENBACH, Scott, D. ,  EFTIMIE, Antoaneta, C. ,  LY, Kevin, S.

IPC分类号： A61M31/00

CPC分类号： A61K9/0004

摘要： The present invention relates to an osmotically driven agent delivery system for delivering a beneficial agent. The osmotic delivery system includes an osmotic agent which operates by imbibing fluid from an outside environment, causing the release of a beneficial agent. The osmotic delivery system includes a liquid or gel additive surrounding the osmotic agent for enhancing start-up and lubricating the osmotic agent. The liquid or gel additive is an incompressible lubricating fluid which fills any air gaps between the osmotic agent and the walls of a chamber and substantially reduces start-up delays.

公开(公告)号：EP1041974A1

公开(公告)日：2000-10-11

申请号：EP98935755.3

申请日：1998-07-24

申请人： ALZA CORPORATION

发明人： CHEN, Guohua ,  DIONNE, Keith, E. ,  HOM, Lawton ,  LAUTENBACH, Scott, D.

IPC分类号： A61K9/52

CPC分类号： A61K9/0004

摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule containing a beneficial agent and an osmotic agent which swells on contact with water causing the release of the beneficial agent over time. The osmotic delivery system has a membrane plug which allows water to pass through the plug from an exterior of the capsule while preventing the compositions within the capsule from passing out of the capsule. A delivery rate for delivery of the beneficial agent from the implant capsule is controlled by varying a core diameter of the membrane plug within a constant diameter capsule. The membrane plug has a variable water permeation rate depending on an extent to which the membrane plug is constrained by the capsule walls.

公开(公告)号：EP1011642A2

公开(公告)日：2000-06-28

申请号：EP98937963.1

申请日：1998-07-24

申请人： ALZA CORPORATION

发明人： CHEN, Guohua ,  DIONNE, Keith, E. ,  LAUTENBACH, Scott, D. ,  JORDAN, Scott, D. ,  BERRY, Stephen, A. ,  RODENBERGER, Craig, I. ,  AYER, Rupal

IPC分类号： A61K9/52

CPC分类号： A61K9/0004

摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.

公开(公告)号：EP1551493B1

公开(公告)日：2007-10-31

申请号：EP03762060.6

申请日：2003-06-25

申请人： Alza Corporation

发明人： LAUTENBACH, Scott, D.

IPC分类号： A61M31/00 ,  A61K9/00

CPC分类号： A61K9/48 ,  A61K9/0004 ,  A61M31/002 ,  A61M2005/14513

摘要： An osmotic pump having a minimally compliant, volume efficient piston positioned within a capsule. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length to total diameter ratio of about 1.1:1 and a core diameter to total diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

公开(公告)号：EP1041974B1

公开(公告)日：2006-10-11

申请号：EP98935755.3

申请日：1998-07-24

申请人： ALZA CORPORATION

发明人： CHEN, Guohua ,  DIONNE, Keith, E. ,  HOM, Lawton ,  LAUTENBACH, Scott, D.

IPC分类号： A61K9/52

CPC分类号： A61K9/0004

摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule containing a beneficial agent and an osmotic agent which swells on contact with water causing the release of the beneficial agent over time. The osmotic delivery system has a membrane plug which allows water to pass through the plug from an exterior of the capsule while preventing the compositions within the capsule from passing out of the capsule. A delivery rate for delivery of the beneficial agent from the implant capsule is controlled by varying a core diameter of the membrane plug within a constant diameter capsule. The membrane plug has a variable water permeation rate depending on an extent to which the membrane plug is constrained by the capsule walls.

公开(公告)号：EP0877599B1

公开(公告)日：2003-03-26

申请号：EP97902971.7

申请日：1997-01-15

申请人： ALZA CORPORATION

发明人： ECKENHOFF, James, B. ,  PEERY, John, R. ,  DIONNE, Keith, E. ,  LANDRAU, Felix, A. ,  LAUTENBACH, Scott, D. ,  MAGRUDER, Judy, A. ,  WRIGHT, Jeremy, C.

IPC分类号： A61K9/00

CPC分类号： A61K9/0004 ,  A61K9/0024 ,  A61K38/09 ,  A61M5/14526 ,  A61M2005/14513 ,  A61M2206/10

公开(公告)号：EP0877599A1

公开(公告)日：1998-11-18

申请号：EP97902971.0

申请日：1997-01-15

申请人： ALZA CORPORATION

发明人： PEERY, John, R. ,  DIONNE, Keith, E. ,  LANDRAU, Felix, A. ,  LAUTENBACH, Scott, D. ,  MAGRUDER, Judy, A. ,  WRIGHT, Jeremy, C.

IPC分类号： A61K9 ,  A61K38 ,  A61K45 ,  A61M5

CPC分类号： A61K9/0004 ,  A61K9/0024 ,  A61K38/09 ,  A61M5/14526 ,  A61M2005/14513 ,  A61M2206/10

摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.